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The Effect of Semaglutide on Bone Turnover in Patients With Increased Risk of Bone Fracture

Osteopenia Clinical Trial

Official title:
The Effect of Semaglutide (Ozempic) on Bone Turnover in Patients With Increased Fracture Risk: a Randomized Placebo-controlled Clinical Trial

Clinical Trial Summary

The hypothesis for this study is that the GLP-1Ra Semaglutide has a positive effect on the balance between build-up and degradation as well as the strength of the bones in men and women aged 40-85 years at increased risk of bone fractures. Treatment involves injection of Semaglutide 1.34 mg/ml once a week or corresponding volume of placebo once a week for 52 weeks. The effect will be measured by bone markers in blood samples, bone scans, bone tissue tests (bone biopsy), and direct bone strength measured by microindentation at the start and end of the study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04702516
Study type Interventional
Source Odense University Hospital
Contact Morten Steen Svarer Hansen, MD
Phone +4521249531
Email morten.steen.hansen@rsyd.dk
Status Recruiting
Phase Phase 1/Phase 2
Start date March 24, 2021
Completion date August 31, 2022
View Details
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