Osteopenia Clinical Trial
Official title:
Safety and Pharmacokinetics of Orally Administered Strontium L-Lactate in Healthy Adults
No clinical trials have evaluated strontium L-lactate (SrLac), the strontium salt of the L-enantiomer of lactic acid. Therefore, this clinical study was conducted to obtain general safety and pharmacokinetic (PK) information following acute oral intakes of three doses of SrLac by healthy adults. The data provided valuable comparisons with the pharmacokinetics of other strontium salts that are in clinical use and allowed determination of the dose of SrLac that will be useful for the management of bone health.neficial for the treatment of low bone density of osteoporosis and osteopenia.
Purpose: The aim of this clinical study was to obtain safety and pharmacokinetic information
following acute oral intakes of three ascending doses of strontium L-lactate by healthy
adults.
Subjects and methods: Ten healthy men and women, mean age 43 ± 2 years, ingested one of three
ascending doses of strontium L-lactate (SrLac) once per week for three weeks in succession.
Fasting blood collections were performed pre-dose and 1, 2, 3, 4, 5, 6, 8 and 12 hours
post-dose for determination of serum strontium at each interval.
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