Osteopenia Clinical Trial
Official title:
Effects of Whole Body Vibration (WBV) on Musculoskeletal System of Aged Women
A controlled, non-randomized trial will be carried out in 240 postmenopausal women, aged
55-75 years, over a 18-month period. The group 1 received a physical intervention,
consisting of whole body vibration (WBV) over 12 months followed by training arrest during 6
months. The group 2 served as sedentary control. WBV training is performed 2 or 3 times per
week, with each session lasting 20 minutes. The training included light squats at 35-50 Hz
and ended up by stretching and relaxation exercises at 50 Hz. Bone, muscle and postural
evaluations will be performed at the beginning, 6, 12 and 18 months in each group with
evaluation of bone micro-architectural trabecular and cortical compartments, at the weight
bearing tibia and the non weight bearing radius.
The primary outcome of the project is the pre, mid, and post evaluations of bone. Bone
exploration included dual x-ray absorptiometry (DXA) and high resolution peripheral
quantitative computed tomography (HR-pQCT). Bone Mass Density (BMD) will be evaluated by DXA
at lumbar, femoral levels and humeral, macro and micro-architectures of the cortical and
trabecular compartments will be evaluated in distal radius and tibia by HR-pQCT and bone
markers will be analyzed longitudinally. The secondary aim is to assess muscle performance
and proprioception. Finally will be assessed markers of cartilage degradation and synthesis,
no study has been published on this tissue.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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