Osteomyelitis Clinical Trial
Official title:
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
The feet of diabetic patients continue to be an important problem in medicine. In general, patients with diabetic foot have some sort of amputation, especially in underserved populations. It is clearly necessary to develop novel treatment strategies for this worldwide health problem. Photodynamic therapy (PDT) , is a low cost and highly effective alternative treatment concerning infections avoiding amputations in the diabetic foot.
Patients with infected diabetic foot were grouped according to the Wagner system for
classifying foot lesions. All patients presented Wagner Grade 3 classification, with
osteomyelitis in one or more toes. The study included only patients who had circulatory
viability.
For PDT treatment the fistula and/or ulcer was used as a gateway to the bone. The treated
area (bones and fingers) was irrigated with a solution of phenothiazinium salts. After that,
light irradiation was performed with optical fibers or led device above the wound. PDT
treatment always in outpatients, once or twice a week.
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