Clinical Trials Logo

Clinical Trial Summary

The main objective is to study the efficacy of denosumab in reducing wear-induced osteolysis around uncemented acetabular implants used in total hip arthroplasty. Patients included in the study will receive the same dose of 60 mg denosumab or placebo (1 ml solution) for a total of 6 doses with start on day one and every 6 months with last treatment at 30 months. The primary endpoint will be the change in volume of the osteolytic lesion over 3 years measured (measured with 3D-CT in cm³).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02299817
Study type Interventional
Source Danderyd Hospital
Contact
Status Active, not recruiting
Phase Phase 2
Start date August 2015
Completion date February 2021

See also
  Status Clinical Trial Phase
Completed NCT01272830 - Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements Phase 2
Completed NCT00367289 - CT for Diagnosis of Implant Stability in Revision Arthroplasty N/A
Recruiting NCT05018130 - Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies N/A
Not yet recruiting NCT06041828 - Regular Home-use Dual Light Photodynamic Therapy in the Prevention of Osteolysis After Dental Implant Surgery N/A
Terminated NCT01464645 - Post-Market Study of the Modular Revision Hip System
Completed NCT01198457 - Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment N/A
Active, not recruiting NCT04255966 - Plasmafit® Revision Structan® Hip Endoprosthesis Cup