Osteogenesis Imperfecta Clinical Trial
The coming out of Next Generation Sequencing (NGS) technologies, with documented advantages
and reduced costs respect to Sanger sequencing, has provided new appealing approaches to
diagnostic testing. Despite this, its use for routine diagnostic purposes requires
certification in terms of reliability, as well as a cost-effectiveness evaluation.
To test the feasibility of using the Ion Torrent Personal Genome Machine (PGM) in clinical
diagnosis, we assessed its performance to detect point mutations and big rearrangements
previously identified with standard techniques. The diagnostic accuracy and the
cost-effectiveness will be evaluated by Health Technology Assessment (HTA) analyses.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02531087 -
Urinary Biomarkers of OI Pathobiology
|
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| Completed |
NCT01713231 -
Effect of High-Dose Vitamin D on Bone Density in Osteogenesis Imperfecta
|
Phase 4 | |
| Completed |
NCT00655681 -
Prevention of Post Operative Bone Loss in Children
|
N/A | |
| Recruiting |
NCT06065111 -
Study of Osteogenesis Imperfecta Tendon
|
||
| Withdrawn |
NCT03216486 -
An Exploratory Study of BPS804 Treatment in Adult Patients With Type I, III or IV Osteogenesis Imperfecta
|
Phase 2 | |
| Recruiting |
NCT06086613 -
A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04009733 -
Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study
|
N/A | |
| Completed |
NCT04231916 -
High Resolution Thermal Imaging to Identify Vertebral Fractures in Children and Young People With Osteogenesis Imperfecta
|
N/A | |
| Active, not recruiting |
NCT02814591 -
Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy
|
||
| Completed |
NCT00982124 -
An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfecta
|
Phase 3 | |
| Not yet recruiting |
NCT05612139 -
Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients
|
||
| Completed |
NCT00001305 -
Growth Hormone Therapy in Osteogenesis Imperfecta
|
Phase 3 | |
| Completed |
NCT04119388 -
Evaluation of the Benefits of Adaptive Physical Activity in Children and Adolescents With Osteogenesis Imperfecta
|
N/A | |
| Terminated |
NCT01679080 -
The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta
|
Phase 2 | |
| Completed |
NCT00106028 -
Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Children
|
Phase 3 | |
| Recruiting |
NCT04152551 -
Effects of Bisphosphonates on OI-Related Hearing Loss
|
Phase 4 | |
| Completed |
NCT00705120 -
Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantation
|
Phase 1 | |
| Suspended |
NCT04169568 -
Osteogenesis Imperfecta Blood Pressure Study
|
||
| Completed |
NCT03064074 -
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta
|
Phase 1 | |
| Not yet recruiting |
NCT05258019 -
Site Preservation After Tooth Extraction
|