Clinical Trials Logo
  1. Home
  2. Osteochondritis Dissecans
  3. NCT01694823

Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects — CS-ACI  

Joint Diseases Clinical Trial

Official title:
A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation（CS-ACI）for the Treatment of Articular Cartilage Defects

Clinical Trial Summary

In this study,the Autologous chondrocyte implantation (ACI)technology and cell sheet technology are used to Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI) for treating Cartilage Defects.The Safety and Efficacy Study of CS-ACI are evaluated.

Clinical Trial Description

All procedures are carried out after obtaining informed written consent from patients. Cartilage tissue is acquired from the Non-weight-bearing area of patients. chondrocyte are isolated and grown in culture for 6-8 weeks. After this time interval, the cells are reprocessed and the cell sheet is obtained. Implantation of the chondrocyte sheet into the Cartilage defect of the keen.The patients will be assessed clinically with scoring systems preoperatively as well as 24 months postoperatively to assess relief of symptoms and joint function. Radiological assessment (MRIs)of the affected joints will be performed at the same time points aforementioned to assess integrity of the formed cartilage. Second look arthroscopy and biopsy will also be performed to histologically assess the repair tissue and grade it via arthroscopic grading system according to the International Cartilage Repair Society guidelines. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01694823
Study type Interventional
Source Fourth Military Medical University
Contact
Status Recruiting
Phase Phase 1/Phase 2
Start date April 2012
Completion date June 2015
View Details
See also
  Status Clinical Trial Phase
Withdrawn NCT04976972 - A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation N/A
Not yet recruiting NCT03726788 - Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis Phase 2
Completed NCT02944448 - A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee Phase 2
Completed NCT02604446 - Depot-opioids for Pre- and Postoperative Pain Relief After Primary Knee Arthroplasty.Tapentadol vs Oxycodone vs Placebo Phase 3
Completed NCT02256098 - RSA RCT: ATTUNE™ TKA Versus PFC Sigma TKA N/A
Completed NCT02269254 - Persona Versus NexGen N/A
Completed NCT00815243 - Telemedicine Consultation in Trauma and Orthopedic N/A
Recruiting NCT05564182 - High Intensity Laser Therapy in the Treatment of Hemiplegic Shoulder Pain N/A
Recruiting NCT06142669 - EVOLUTION® Revision STEMMED CS Post Market Clinical Follow-up Study Protocol
Enrolling by invitation NCT04147559 - Post Market Clinical Follow-Up Study for PROFEMUR® Preserve Classic Femoral Stem
Terminated NCT02591368 - MiniTightRope Suspensionplasty Compared With LRTI for the Treatment of Basilar Thumb Arthritis N/A
Completed NCT01227694 - Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis Phase 1/Phase 2
Completed NCT00784277 - A Study to Compare the Frequency of Constipation Symptoms With Tapentadol Immediate Release (IR) Treatment Versus Oxycodone IR Treatment in Patients With End-stage Joint Disease Phase 3
Active, not recruiting NCT05618782 - Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee Phase 2
Recruiting NCT04029792 - Evaluation of a Combination of Plant Extracts (BSL_EP028) on Joint Mobility Phase 1/Phase 2
Active, not recruiting NCT06404346 - Comparative Effectiveness of HVT and Bowen Technique in Patients of SI Joint Dysfunction With Upslipped Innominates N/A
Terminated NCT04712019 - Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA N/A
Completed NCT05650970 - Radial Nerve Mobilization in Hand Thumb Osteoarthritis Patients N/A
Recruiting NCT06074744 - Subsartorial Nerve Block and Femoral Nerve Block in Total Knee Arthroplasty N/A
Completed NCT02315664 - MONITOR-OA: Using Wearable Activity Trackers to Improve Physical Activity in Knee Osteoarthritis N/A