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Osteochondral Lesion of Talus clinical trials

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NCT ID: NCT06358807 Recruiting - Clinical trials for Osteochondral Lesion of Talus

Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral lesion of the talus (OLT). The interface integration of the injured area will also be assessed via radiographic follow-up. The main questions it aims to answer are: - Does arthroscopic microfracture combined with PRP gel injection improve ankle function of participants based on American Orthopedic Foot and Ankle Society (AOFAS) Score? - Does arthroscopic microfracture combined with PRP gel injection improve interface integration of the injured cartilage on magnetic resonance imaging (MRI)? Researchers will compare arthroscopic microfracture with concomitant local injection of PRP gel to isolated microfracture to see if intraoperative PRP gel injection adds clinical efficacy to isolated arthroscopic microfracture in treatment of OLT. Participants will: - Undergo either isolated arthroscopic microfracture or microfracture with intraoperative injection of PRP gel - Receive clinical follow-up 3, 6, 12, and 24 months after surgery and answer scales of ankle function assessment - Take MRI preoperatively and 6, 12 and 24 months after surgery

NCT ID: NCT05741983 Withdrawn - Clinical trials for Osteochondral Lesion of Talus

AMIC vs. MFx in the Ankle

AMARTA
Start date: April 28, 2023
Phase: N/A
Study type: Interventional

This clinical investigation is a prospective, double blind, single-centre, randomised controlled trial comparing arthroscopic autologous matrix induced chondrogenesis (AMIC®) to microfracture alone in the treatment of osteochondral and chondral lesion in the ankle to evaluate effectiveness, performance and safety of AMIC® procedure versus microfracture (MFx).

NCT ID: NCT05476692 Not yet recruiting - Clinical trials for Osteochondral Lesion of Talus

Clinical Outcome of Surgical Treatment for Osteochondral Lesions of the Talus

Start date: October 1, 2022
Phase:
Study type: Observational

Assess clinical and radiological outcome of the various surgical techniques for treatment of osteochondral lesions of the talus

NCT ID: NCT04475341 Not yet recruiting - Clinical trials for Osteochondral Lesion of Talus

Osteochondral Lesions Under 15mm2 of the Talus; is Iliac Crest Bone Marrow Aspirate Concentrate the Key to Success?

OUTBACK
Start date: September 1, 2020
Phase: N/A
Study type: Interventional

Osteochondral defects (OCDs) of the talus have a significant impact on the quality of life of patients. When OCDs are of small nature (up to 15 mm in diameter), and have failed conservative management, surgical intervention may be necessary. For small cystic defects the current treatment is an arthroscopic bone marrow stimulation (BMS) procedure, during which the damaged cartilage is resected and the subchondral bone is microfractured (MF), in order to disrupt intraosseous blood vessels and thereby introduce blood and bone marrow cells into the debrided lesion, forming a microfracture fibrin clot, which contains a dilute stem cell population from the underlying bone marrow. This procedure has been reported to have a 75% successful long-term outcome. Recently, the additional use of biological adjuncts has become popular, one of them being bone marrow aspirate concentrate (BMAC) from the iliac crest. BMAC consists of mesenchymal stem cells, hematopoietic stem cells and growth factors, which may therefore theoretically improve the quality of subchondral plate and cartilage repair. The current evidence for treating talar OCDs with BMS plus BMAC is limited and heterogeneous. It is unclear to what extent the treatment of talar OCDs with BMS plus BMAC is beneficial in comparison to BMS alone.

NCT ID: NCT04194970 Completed - Clinical trials for Osteochondral Lesion of Talus

Monitoring of Weight Bearing Protocols Via Mobile Application and Pressure Sensors.

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

Randomized, prospective, double-blind study: Avascular, anöral and non-regenerative cartilage tissue mostly repaired via arthroscopic surgeries. After that, the patients rehabilitate with optimum weight bearing protocols in post-operative and discharge periods by physiotherapists. In the post-operative period, optimum weight bearing is vital for this tissue healing. There is not any opportunity or device to follow up the compliance of patients to weight bearing. We aimed to develop a device with mobile application to monitor the compliance the patients to weight bearing protocols. This device is designed to could give negative live feedback (with visual audible and vibrating warnings) in order to ensure the compliance of patients. Thanks to the device, health professionals will also have the opportunity to monitor the patient's compliance with the protocol on a daily basis. We hypothesized that patients monitored with this device may have a better recovery.

NCT ID: NCT04132076 Enrolling by invitation - Ankle Arthritis Clinical Trials

Treatment Outcome After Ankle Joint Surgeries

Start date: April 17, 2019
Phase:
Study type: Observational

Osteochondral lesion of talus (OLT), osteoarthrosis and impingement/instability syndrome are most common ankle joint pathologies. This study analyses outcome after various different operative treatment of aforementioned pathologies. Investigators hypothesis is that patient characteristics, type of lesion and surgical technique affect the result of treatment. The investigators will compare subjective (questionnaire) and objective (clinical examination) status of patient before and after operation.

NCT ID: NCT03856021 Enrolling by invitation - Clinical trials for Osteochondral Lesion of Talus

Microfracture vs. Microfracture and BMAC for Osteochondral Lesions of the Talus

Start date: October 18, 2018
Phase: N/A
Study type: Interventional

Osteochondral lesions of the talus are thought to be due in large part to traumatic events or repetitive microtrauma that causes damage to both the articular cartilage and the subchondral bone. There are several treatment modalities for osteochondral lesions of the talus but there is no consensus as to which is the superior method for repair. Treatment modalities are aimed at regenerating articular cartilage. Microfracture is a widely accepted and utilized treatment for osteochondral lesions. This procedure results in pluripotent bone marrow stem cells filling the defect and ultimately differentiating into fibrocartilage-producing cells [1]. This technique has shown good results in both short- and medium-term follow-up for smaller lesions. Bone marrow aspirate contains mesenchymal stem cells and growth factors with cartilage regeneration potential. Bone marrow aspirate concentrate (BMAC) is a treatment modality that has shown to have to potential to produce hyaline cartilage. This study aims to analyze the effect of adding BMAC to the standard microfracture procedure in terms of clinical and radiographic outcomes in comparison to patients who only underwent microfracture treatment.

NCT ID: NCT03750253 Active, not recruiting - Clinical trials for Osteochondral Lesion of Talus

Extracorporeal Shock Wave Therapy for Pain-Relief After Arthroscopy for Osteochondral Lesions of the Talus

Start date: March 1, 2013
Phase: N/A
Study type: Interventional

Arthroscopic surgery is effective in treating osteochondral lesions of the talus. However, there are still some patients with postoperative ankle pain. This study aims to investigate the clinical efficacy of shock wave adjuvant therapy in the treatment of postoperative pain caused by cartilage injury of talus after arthroscopy and to provide basis for further popularization and application.

NCT ID: NCT02345564 Active, not recruiting - Clinical trials for Osteochondral Lesion of Talus

Clinical and Radiological Results of Osteochondral Repair Using MaioRegen in Knee and Ankle Surgery

Start date: March 2012
Phase: N/A
Study type: Interventional

Osteochondral lesions in knee and ankle are injuries commonly seen in young patients. MaioRegen fleece is a cartilage substitute which can be used in circumscribed defects. This prospective study follows patients treated with MaioRegen implants from pre-surgery until 24 months post-surgery.

NCT ID: NCT02338375 Enrolling by invitation - Clinical trials for Osteochondral Lesion of Talus

Safety and Efficacy of Allogenic Umbilical Cord Blood-derived Mesenchymal Stem Cell Product

Cartistem
Start date: December 2012
Phase: Phase 0
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of adding allogenic umbilical cord blood-derived stem cell product(Cartistem®) on currently standard treatment of arthroscopic curettage and microfracture for osteochondral lesion of talus.