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Osteitis Deformans clinical trials

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NCT ID: NCT02106455 Completed - Clinical trials for Osseous Paget's Disease

Sodium Risedronate Tablets - Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) -48-week Surveillance −

Start date: August 1, 2008
Phase:
Study type: Observational

The purpose of this study is to evaluate the safety and efficacy of sodium risedronate tablets administered once daily (one tablet per dose) in patients with osseous Paget's disease for 48 weeks from baseline in daily medical practice.

NCT ID: NCT00774020 Completed - Clinical trials for Paget's Disease of Bone

Efficacy and Safety of Single Dose of 5 mg Zoledronic Acid in Chinese Patients With Paget's Disease of Bone (PDB)

Start date: October 30, 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to document the efficacy and safety profiles of single intravenous dose of 5 mg zoledronic acid for the Chinese patients of Paget's Disease of Bone (PDB).

NCT ID: NCT00747994 Completed - Clinical trials for Paget's Disease of Bone

Genetic Study of Families Affected by Paget's Disease of Bone

PAGET
Start date: September 2007
Phase: N/A
Study type: Observational

Paget's disease of bone is a frequent bone disorder which usually starts after the age of 40 and which is characterized by bone pain and deformities. Although often without any symptoms, this disease may have severe complications such as fissures, fractures, neurological compression, or deafness. In some cases, it is a genetic disorder transmitted with a dominant autosomal pattern of inheritance: one of the two parents carrying the disease transmits it to his offspring with a risk of 50% for each child. Since 2002, the first gene involved in Paget's disease of bone is known and 14 mutations of this gene have been published. A study confirmed that the presence of those mutations was associated with younger age of onset and more extensive disease. Thus, the knowledge of those genetic factors in the relatives of an affected individual allows the screening of the patients with a higher risk for complications, who may benefit from a medical follow up and earlier treatment, in order to avoid complications. Indeed, Paget's disease of bone may be treated efficiently by bisphosphonates. This project aims at identifying and collecting over one year, 15 affected individuals affected by Paget's disease of bone and the relatives up to the second degree of relativeness (a total of 100 individuals is expected). The blood samples may be analysed in order to search for mutations of the previously known gene and/or to search for new mutations on new genes.

NCT ID: NCT00740129 Completed - Clinical trials for Paget's Disease of the Bone

Re-treatment of Participants With Paget's Disease Using Zoledronic Acid

Start date: October 21, 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study was to demonstrate that participants with Paget's disease of the bone who had responded to zoledronic acid treatment as participants in the core registration studies CZOL446K2304 and CZOL446K2305 and later experienced a relapse can be successfully treated with a 5 milligram (mg) infusion of zoledronic acid.

NCT ID: NCT00668200 Completed - Hypocalcemia Clinical Trials

Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast®

Start date: May 2008
Phase: Phase 4
Study type: Interventional

This study will evaluate the impact of investigator and patient education and educational materials to foster calcium and vitamin D supplementation to mitigate the potential for hypocalcemia post Reclast® administration in patients with Paget's disease of bone.

NCT ID: NCT00480662 Completed - Clinical trials for Paget's Disease of Bone

A Research Study to Test the Effectiveness of MK0217 in Patients With Paget's Bone Disease (0217-206)(COMPLETED)

Start date: October 2001
Phase: Phase 3
Study type: Interventional

To test the safety, effectiveness of MK0217 when taken once a week for six months in treating patients with Paget's bone disease.

NCT ID: NCT00306046 Completed - Clinical trials for Paget's Disease of Bone

18F-Fluoride Positron Emission Tomography (PET) in Paget's Disease of Bone

Start date: February 2002
Phase: N/A
Study type: Interventional

18 F-fluoride Positron emission tomography (PET) is able to demonstrate and quantify the metabolic activity locally in the skeleton (1). This technique should, therefore, also be able to demonstrate a dramatic decrease in the metabolic activity in localized monostotic Paget’s disease lesions after therapy. In this condition, indeed, the usual biological markers may be unhelpful to assess the efficacy of therapy, because they are usually comprised in the normal range for single pagetic localizations, even before therapy (2). The main purpose of this trial is to assess the early and long term response of pagetic bone to bisphosphonate therapy.

NCT ID: NCT00159419 Completed - Osteoporosis Clinical Trials

Bisphosphonate Therapy for Osteogenesis Imperfecta

Start date: August 1999
Phase: Phase 4
Study type: Interventional

The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." We, the researchers at Indiana University School of Medicine, are characterizing the changes effected by oral bisphosphonate therapy and comparing them to a regimen of intravenous bisphosphonate therapy in a group of children with OI and also in children with other disorders that result in low bone mass and fractures.

NCT ID: NCT00103740 Completed - Clinical trials for Paget's Disease of Bone

Safety and Efficacy Trial With Zoledronic Acid for the Treatment of Paget's Disease of Bone, Including an Extended Observation Period

Start date: April 2002
Phase: Phase 3
Study type: Interventional

The primary objective of this core study was to show non-inferiority of zoledronic acid to risedronate, with respect to the proportion of patients who achieved therapeutic response. The extended observation period included participants of the core study who responded to treatment.

NCT ID: NCT00051636 Completed - Clinical trials for Paget's Disease of Bone

Safety and Efficacy Trial With Zoledronic Acid for the Treatment of Paget's Disease of Bone, Including an Extended Observation Period

Start date: January 2001
Phase: Phase 3
Study type: Interventional

The core study looked at the effect of Zoledronic Acid given once as an intravenous (i.v.) infusion compared to 60 days of oral Risedronate in patients with Paget's disease of bone. The effect was demonstrated in the reduction of serum alkaline phosphatase (SAP). The extended observation period included participants of the core study who responded to treatment.