The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

Orthopedic Disorders Clinical Trial

Official title:

The Different Analgesic Potency of Sevoflurane and Desflurane at Equi-minimum Alveolar Concentration

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02609802
• Other study ID #: 2015-09-028
• Status: Completed
• Phase: Phase 3
• First received: November 18, 2015
• Last updated: November 6, 2017
• Start date: November 2015
• Est. completion date: July 28, 2016

Study information

• Verified date: November 2017
• Source: Kangbuk Samsung Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Description:

Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 77
• Est. completion date: July 28, 2016
• Est. primary completion date: July 28, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients undergoing arthroscopic shoulder surgery

• patients with american society of anesthesiologist physical status I, II

• patients aged 19-65 years

• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any psychiatric or neurological disease

• patients who had received any medication affecting the central nervous system

• patients who had received medication affecting the sympathetic or parasympathetic nervous systems

• patients who have not received interscalene approach brachial plexus block (refusal or failure)

• pregnant women

Related Conditions & MeSH terms

• Musculoskeletal Diseases
• Orthopedic Disorders

Intervention

Drug:
• Sevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.
• Desflurane
Anesthesia was maintained with desflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.

Locations

Country	Name	City	State
Korea, Republic of	Kangbuk Samsung Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Kangbuk Samsung Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Analgesic potency of volatile anesthetics	The analgesic potency was evaluated by surgical pleth index value	the first 60 min of maintaining a steady state 1 MAC of volatile agents