Neurologic Disorder Clinical Trial
Official title:
Plasticity of Chronically Compressive Spinal Cord After Surgical Decompression - A fMRI Study
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly. Hong Kong is facing a heavy social economic burden from CM with the rapidly aging population. Surgical decompression is considered as the mainstay of the treatment for CM patients to relieve their symptoms and signs. Yet the surgical outcome is not always satisfactory. There is a pressing need for understanding the exact mechanism of surgical decompression on the recovery of myelopathic cord in order to improve the prognosis of CM patients in near future.This project will evaluate neuronal activities and axon regeneration by longitudinally monitoring at time zero, 3 and 6 month after the surgery in CM patients using UTE, BOLD-fMRI and DTI, and to investigate the relationship of preoperative neuronal activities of myelopathic cord with axon regeneration.
This study aims to monitor the structural and functional changes of chronically compressed spinal cords longitudinally after surgical decompression in vivo. Three kinds of MRI techniques will be used in this study. These are (1) axial T1-weighted (T1WI) and T2-weighted imaging (T2WI), UTE MRI, (2) BOLD-based fMRI, and (3) diffusion tensor imaging (DTI). To quantitatively investigate the structural deficits, T1/T2 MRIs will delineate the gross morphology of the spinal cord, CSF, and surrounding anatomical structures, while DTI will quantify the fiber orientation and integrity within the spinal cord. BOLD-based functional MRIs will assess the local hemodynamic changes and neuron activities in response to the motor or sensory stimulation along the C3 to C8 spinal nerve levels. The MRI evaluations will be applied to the same cervical myelopathy (CM) patient before surgery and 3 and 6 months post-surgery, when clinical recovery reaches a plateau9. Clinical examination will include neurological evaluation, Japanese Orthopaedic Association (JOA) scoring assessment, and clinical electrophysiological evaluation. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05519592 -
Proximal Lower Limb Intramuscular Block : Effects on Hemiparetic Gait
|
N/A | |
Recruiting |
NCT04098679 -
Childhood Adiposity and Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes (CONCEPTT Kids)
|
||
Completed |
NCT03946137 -
Chest Therapy and Postural Education in Children With Cerebral Palsy
|
N/A | |
Completed |
NCT05217186 -
Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
|
||
Not yet recruiting |
NCT05506306 -
Multitissular Effect of Vertical Mobilization Using the Exoskeleton AtalanteTM in Neurological Chair- or Bed-bound Patients
|
||
Recruiting |
NCT04846413 -
Voice Analysis in Patients With Neurologic Diseases
|
||
Recruiting |
NCT05260190 -
Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)
|
N/A | |
Not yet recruiting |
NCT04906681 -
Implementation of a Rehabilitation Technology in Orthopedic and Neurological Rehabilitation to Increase Therapy Dosage: an Exploratory Study
|
Phase 1/Phase 2 | |
Completed |
NCT04743037 -
Interactive Self-Management Augmented by Rehabilitation Technologies
|
N/A | |
Not yet recruiting |
NCT03899298 -
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
|
Phase 1 | |
Active, not recruiting |
NCT04631965 -
Healthcare Transition of Adolescents With Chronic Health Conditions
|
||
Recruiting |
NCT05132517 -
Magnesium and Cognition After Stroke
|
||
Recruiting |
NCT04100993 -
Multisystem and Autonomic Complications of NMD on Long-term NIV
|
||
Recruiting |
NCT05652946 -
IISART (International Industry Society of Advanced Rehabilitation Technology) Advanced Rehabilitation Technology Study
|
N/A | |
Recruiting |
NCT06146543 -
Stress Ball During Lumbar Puncture the Effect of the Application on Anxiety Level
|
N/A | |
Completed |
NCT06368024 -
Establishment of Delphi-MD Safety Performance and Reliability
|
||
Not yet recruiting |
NCT06169696 -
EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis
|
N/A | |
Completed |
NCT03329872 -
Neuro-Orthopedic Registry of the University Hospital of Toulouse
|
||
Completed |
NCT05483244 -
Weaning Success in Different Weaning Strategies in Early Neurological Rehabilitation Patients - a Matched-pair Analysis
|
||
Completed |
NCT04170985 -
NeuroSeq: A Prospective Trial to Evaluate the Diagnostic Yield of Whole Genome Sequencing (WGS) in Adult Neurology
|