Comparative Study of Different Bone Grafts in Accelerating Tooth Movement

Orthodontics Clinical Trial

Official title:

Effectiveness of Bovine Derived Xenograft Versus Bioactive Glass With Periodontally Accelerated Osteogenic Orthodontics in Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02796911
• Other study ID #: 029-16
• Status: Completed
• Phase: N/A
• Start date: September 1, 2015
• Est. completion date: July 1, 2016

Study information

• Verified date: March 2024
• Source: King Abdulaziz University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Objective: Periodontally accelerated osteogenic orthodontics(PAOO) will minimize treatment time. The current study will be carried to evaluate the effectiveness of different bone grafts with a modified, less invasive corticotomy technique in the treatment of adult patients with moderate crowding. Subjects and Methods: Thirty orthodontic patients will be selected. Patients were randomly classified into three groups. Group I will be treated with a modified technique of corticotomy, whereas group II will be treated with the same technique combined with PAOO using bovine derived xenograft, and group III will be treated with the same technique combined with PAOO using with bioactive glass. The total duration of active orthodontic treatment will be estimated. Probing depth, bone density and root length will be also evaluated. The measurements will be recorded.

Description:

Objective: Periodontally accelerated osteogenic orthodontics(PAOO) combines periodontal therapy with orthodontic therapy, which will minimize treatment time. The current study will be carried to evaluate the effectiveness of bovine derived xenograft versus bioactive glass with a modified, less invasive corticotomy technique in the treatment of adult patients with moderate crowding. Subjects and Methods: Thirty orthodontic patients will be selected. Patients were randomly classified into three groups. Group I will be treated with a modified technique of corticotomy on the labial side only, whereas group II will be treated with the same technique combined with PAOO using bovine derived xenograft, and group III will be treated with the same technique combined with PAOO using with bioactive glass. The total duration of active orthodontic treatment will be estimated from the time of starting the active orthodontic treatment, immediately following the corticotomy procedure, to the time of debonding. Probing depth will be evaluated clinically whereas bone density and root length will be evaluated radiographically. The measurements will be recorded at day of surgery (baseline) (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: July 1, 2016
• Est. primary completion date: July 1, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• A moderate 4-5mm crowding of the lower anterior teeth
• Good oral hygiene
• Healthy systemic condition

Exclusion Criteria:

• previous orthodontic treatment
• Probing depth values exceeding 3 mm
• Radiographic evidence of bone loss
• Regular administration medication that affects bone metabolism such as prolonged use of corticosteroids, or bisphosphonates and NSAIDs.

Related Conditions & MeSH terms

• Orthodontics

Intervention

Drug:
• Xenograft
group II will be treated with CAOT combined with bovine derived xenograft (Biogen, Biotecksrl Fermi, Arcugraro VI, Italy);
• Bioactive glass
group III will be treated with CAOT combined with bioactive glass (Bio-Glass, Excellence Pharm Inc., Egypt).

Locations

Country	Name	City	State
Saudi Arabia	King Abdelaziz University. Faculty of dentistry	Jeddah

Sponsors (1)

Lead Sponsor	Collaborator
King Abdulaziz University

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Speed of tooth movement	The total duration of active orthodontic treatment will be estimated in weeks from the time of starting the active orthodontic treatment, immediately following the corticotomy procedure, to the time of debonding.	Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).
Secondary	Bone density	Bone density will be evaluated radiographically	Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).
Secondary	Root length	Root length will be evaluated radiographically	Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).