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Oropharyngeal Cancer clinical trials

View clinical trials related to Oropharyngeal Cancer.

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NCT ID: NCT03890783 Completed - Clinical trials for Oropharyngeal Cancer

Functional Results of Soft Palate Free Flap Reconstruction

RECaVoLL
Start date: February 27, 2019
Phase:
Study type: Observational

The oropharynx is a complex anatomical structure necessary for nasal breathing, swallowing and phonation. The removal of oropharyngeal cancers can lead to sequelae, particularly in the case of resections affecting the soft palate. The main sequelae are represented by rhinolalia and swallowing disorders with nasal regurgitation. The treatment of oropharyngeal tumors is based on primary surgery or radiotherapy, but tumors of the soft palate are often treated by radiotherapy or radio-chemotherapy first. Surgery is often kept for relapses, because it is considered to lead to important sequelae. However, chemoradiotherapy of the oropharynx is also responsible for acute toxicities, and late sequelae can be frequent and important. Recent publications tend to show that primary surgery would give better survival rates compared to radiotherapy, particularly in advanced stages, including viro-induced cancers. In addition, primary surgery can reduce the dose of radiation delivered to the oropharynx and thus reduce its long-term toxicity. It is currently possible to reconstruct a loss of substance after surgery of oropharyngeal cancers, including the soft palate by using free flaps, limiting the postoperative sequelae usually observed without reconstruction. There is little data on reconstructions of the soft palate, their sequelae and their impact on the quality of life.

NCT ID: NCT03822897 Active, not recruiting - Clinical trials for Oropharyngeal Cancer

De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma

EVADER
Start date: June 28, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to find out whether radiotherapy to some of the lymph node areas can be safely omitted to decrease side effects without increasing the risk of the tumour coming back.

NCT ID: NCT03777384 Active, not recruiting - Clinical trials for Oropharyngeal Cancer

EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers

Start date: October 12, 2018
Phase:
Study type: Observational

A prospective, observational study evaluating the durability of local/regional control of previously published de-escalated radiotherapy protocols for patients with P16 positive oropharynx cancers who have minimal nicotine exposure who are not current uses (< 10 pack year smoking history; < 10 year history of any nicotine product [electronic cigarette, chewing tobacco]). Quality of Life measures will also be collected.

NCT ID: NCT03729518 Active, not recruiting - Clinical trials for Squamous Cell Carcinoma

TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

Start date: October 11, 2018
Phase: N/A
Study type: Interventional

This is a single-arm Phase II study of adjuvant radiation for locally advanced p16+ oropharyngeal squamous cell carcinoma. The main purpose of this research is to determine the likelihood of cancer growing back in the throat or in the neck two years after completion of radiation if lower doses of radiation are used to a smaller area of the head and neck region than is currently used in standard of care.

NCT ID: NCT03713021 Terminated - Clinical trials for Oropharyngeal Cancer

TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers

Start date: May 15, 2019
Phase: N/A
Study type: Interventional

The purpose of this research study is to look at how using an injectable marker called TraceIT can help with the radiation treatment planning process. TraceIT is a gel that dissolves in the body over time and can be injected and is visible on many types of images that can be used in the treatment planning process. If the exact edges of negative tumor margins can be marked before treatment planning, it is thought that the area receiving radiation can be more personalized, thus potentially reducing unnecessary radiation to areas that are cancer-free.

NCT ID: NCT03691441 Active, not recruiting - Clinical trials for Oropharyngeal Cancer

Comparative Effectiveness Trial of Transoral Head and Neck Surgery Followed by Adjuvant Radio(Chemo)Therapy Versus Primary Radiochemotherapy for Oropharyngeal Cancer

Start date: January 5, 2018
Phase: Phase 4
Study type: Interventional

Comparative Effectiveness Trial of Transoral Head and Neck Surgery followed by adjuvant Radio(chemo)therapy versus primary Radiochemotherapy for Oropharyngeal Cancer

NCT ID: NCT03656133 Active, not recruiting - Clinical trials for Oropharyngeal Cancer

Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers

Start date: September 26, 2018
Phase: N/A
Study type: Interventional

This study is to determine whether a mathematical model can be used to choose a radiation delivery method to improve the rate of a rapid response.

NCT ID: NCT03644563 Active, not recruiting - Clinical trials for Human Papilloma Virus

Men and Women Offering Understanding of Throat HPV

MOUTH
Start date: April 3, 2017
Phase:
Study type: Observational [Patient Registry]

This study will screen people for oncogenic oral Human Papillomavirus (HPV) infection and antibodies to form a cohort of people who may be at increased risk of HPV-oropharyngeal cancer (HPV-OPC). The investigators will follow these individuals prospectively to evaluate oncogenic oral HPV persistence, risk factors, and biomarkers for persistence.

NCT ID: NCT03604588 Recruiting - Clinical trials for Oropharyngeal Cancer

Evaluation of HPV OncoTect ™ for the Etiological Diagnosis of HPV-induced Oropharyngeal Cancers

HPV OncoTect™
Start date: January 17, 2018
Phase: N/A
Study type: Interventional

To determine the sensitivity of HPV OncotectTM to diagnose oropharyngeal cancers induced by oncogenic HPV

NCT ID: NCT03555721 Terminated - Clinical trials for Oropharyngeal Cancer

CytID Analysis of Oral Lesions

Start date: May 30, 2018
Phase:
Study type: Observational

The purpose of this study is to correlate the results from a standard of care biopsy with CytID™ and hpvID™ swab tests for potentially premalignant and malignant oral lesions. The biopsy is considered standard of care and will be performed regardless of the patient's enrollment in the study. The study-related data gathering will not influence the treatment decisions of the clinician.