Organ Transplantation Clinical Trial
Official title:
The Cost-effectiveness Analysis of Immunosuppressants to Postoperative Infection and Death in the Patients With Organ Transplantation
The goal of this observational study is to explore the different immunosuppressive agents and related outcomes in organ transplantation patients in Taiwan. The main question it aims to answer is the risk of different immunosuppressive agents for infection and survival after transplant. The study enrolled patients who underwent solid organ transplant (SOT), kidney (ICD-9-CM code V42.0), liver (ICD-9-CM code V42.7), or lung (ICD-9-CM code V42.6) transplants. We employed propensity score matching (PSM) to establish a matched cohort. The study will compare SOT patients and general patients to explore the risk of different immunosuppressive agents for infection and survival.
Status | Recruiting |
Enrollment | 20000 |
Est. completion date | December 20, 2024 |
Est. primary completion date | November 20, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: - Patients who underwent solid organ transplant (SOT) Exclusion Criteria: - Patients who received more than one SOT, had an infectious disease diagnosis before their SOT or had incomplete medical information in the database. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Chung Shan Medical University | Taichung |
Lead Sponsor | Collaborator |
---|---|
Chung Shan Medical University |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postoperative infection | Postoperative infection contains Pneumocystis jiroveci pneumonia, cytomegalovirus disease, and Herpes simplex virus | From the date of underwent SOTs until the date of incident infection or date of death from any cause, whichever came first, assessed up to 5 years. | |
Primary | Death | Death | From the date of underwent SOTs until the date of death from any cause, assessed up to 5 years. |
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