Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.

Organ Failure, Multiple Clinical Trial

Official title:

Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03933930
• Other study ID #: N201803039
• Status: Withdrawn
• Phase: N/A
• Start date: May 6, 2019
• Est. completion date: May 15, 2021

Study information

• Verified date: May 2020
• Source: Taipei Medical University WanFang Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: May 15, 2021
• Est. primary completion date: May 15, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients receiving hyperthermic intraperitoneal chemotherapy

Exclusion Criteria:

• Unable to set arterial line Severe liver or renal disease Severe heart disease Unconscious patients

Related Conditions & MeSH terms

• Multiple Organ Failure
• Organ Failure, Multiple

Intervention

Other:
• Lactate-directed therapy
If the lactate level elevates, we transfuse pRBC to increase Hct>30%. If Hct >30%, dopamine infusion starts.
• Goal-directed therapy
If SVV>15%, transfuse lactate ringer/normal saline alternatively to keep SVV<15%.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Taipei Medical University WanFang Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pulmonary complication	X-ray findings of airspace or interstitial opacity, lobar consolidation, or pleural effusions; severe respiratory failure requiring respiratory support	1 week
Secondary	Renal complication	oliguria with urine output<0.5 ml/kg/h for more than 4 h, creatinine increase>30 % of preoperative values, dialysis	1 week