Severe Sepsis Clinical Trial
Official title:
Efecto Modulador de la Administracion Del Acido Docosahexaenoico Sobre la Respuesta Inflamatoria, la evolución Clinica y el Estado Nutricional de Neonatos Sometidos a cirugía
The purpose of this study is to evaluate if enteral docosahexaenoic acid (DHA) administration attenuates the inflammatory cytokines and improve clinical outcomes in neonates who underwent cardiovascular surgery
Severe sepsis and organ failure are leading causes of death in surgical patients. Several
studies indicate that a causal relationship exists between the surgical or traumatic injury
and the predisposition to develop septic/infectious complications and multiple organ
failure; this is attributable to uncontrolled inflammatory response. Since neonates have an
immature immune system, they are in a higher risk to develop uncontrolled inflammatory
response and adverse clinical outcomes.
N-3 long chain polyunsaturated fatty acids (L-PUFAs) such as docosapentaenoic and
docosahexaenoic acids (EPA and DHA) have been shown to reduce the inflammatory response by
reducing cytokines, infection rates and length of hospitalization in patients with abdominal
surgery. Therefore, acute and enteral administration of DHA may improve clinical outcomes in
neonates with cardiovascular surgery
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