Oral Submucous Fibrosis Clinical Trial
Official title:
Topical Application of Curcumin Incorporated in Orabase in OSMF Patients
Curcumin (diferuloylmethane) is the chief component of the spice turmeric and is derived from the rhizome of the East Indian plant Curcuma longa. Curcuma longais a member of the Zingiberacae (ginger) family of botanicals and is a perennial plant that is native to Southeast Asia. Turmeric contains a class of compounds known as the curcuminoids, comprised of curcumin, demethoxy curcumin and bisdemethoxycurcumin.
Anti-inflammatory mechanisms implicated in the anticarcinogenic potential of curcumin
include: (1) inhibition of NF-κB and COX-2 (increased levels of COX-2 are associated with
many cancer types); (2)inhibition of arachidonic acid metabolism via lipoxygenase and
scavenging of free radicals generated in this pathway; (3) decreased expression of
inflammatory cytokines IL-1b, IL-6, and TNF-a, resulting in growth inhibition of cancer cell
lines; and (4) down-regulation of enzymes, such as protein kinase C, that mediate
inflammation and tumor-cell proliferation.
Curcumin's potent anti-oxidant and free-radical quenching properties play an important role
in the inhibitory effects of the compound on the initial stages of carcinogenesis.
Antioxidants are implicated in the pathogenesis of OSMF and hence this preparation may be
helpful in resolution of this lesion.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04153266 -
Oral Epithelial Dysplasia Informational Needs Questionnaire
|
||
Not yet recruiting |
NCT06332612 -
Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial
|
Phase 1/Phase 2 | |
Completed |
NCT02711046 -
Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis
|
N/A | |
Completed |
NCT03011086 -
Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis
|
N/A | |
Recruiting |
NCT03511261 -
Efficacy of Curcumin in Oral Submucous Fibrosis
|
Phase 2 | |
Completed |
NCT03732872 -
Epithelial Mesenchymal Transition Markers in OSMF
|
||
Completed |
NCT04476420 -
Comparative Effect of Nigella Sativa and Conventional Management for OSMF
|
Phase 3 | |
Not yet recruiting |
NCT04487938 -
Oral Cancer Screening and Education in Hong Kong
|