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Low-level Laser Therapy on Inflammatory Mediators During Chemotherapy-induced Oral Mucositis — LLLTHSCT  

Oral Mucositis Clinical Trial

Official title:
Effect of Low-level Laser Therapy on Inflammatory Mediators Release During Chemotherapy-induced Oral Mucositis: a Randomized Study

Clinical Trial Summary

The aim of the study is to evaluate the effect of low-level laser therapy (LLLT) on the severity of oral mucositis (OM) and inflammatory mediators (pro- and anti-inflammatory cytokines, metalloproteinases and growth factors) levels in saliva and blood; furthermore, analyze the effect of LLLT in product modulation of oxidative stress and cell damage from the oral mucosa transplant patients.

Clinical Trial Description

This is a randomized clinical trial in which the proposed analysis will be performed from saliva samples of patients transplanted bone marrow, divided into two different groups (control and laser) and collected at different times during the hospitalization of the patient. the group laser receive prophylactic laser therapy, in order to evaluate the effects of LLLT in inflammatory mediators (cytokines pro- and anti-inflammatory) as well as their effect on modulation of oxidative stress products and cell damage (nitric oxide, myeloperoxidase, interleukin-8). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02050373
Study type Interventional
Source Universidade Federal de Goias
Contact
Status Completed
Phase N/A
Start date January 2012
Completion date February 2017
View Details
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