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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT06060301
Other study ID # Faculty of Dentistry, Cairo
Secondary ID
Status Active, not recruiting
Phase Phase 3
First received
Last updated
Start date March 1, 2023
Est. completion date November 20, 2023

Study information

Verified date September 2023
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucosal membrane. T-cell mediated damage against the mucosal epithelial cells is implicated in the pathogenesis of OLP, although the exact mechanism is unknown. Sulfasalazine is extensively used in inflammatory bowel disease and is effective on immune-related inflammatory disease such as Crohn's disease, rheumatoid arthritis, and Behcet's disease. In spite of its effectiveness, the anti-inflammatory mechanism is not clearly understood.


Description:

- Patients will be recruited in a consecutive manner from the outpatient Diagnostic center, Faculty of Dentistry, Cairo University. - A total number of 46 patients will be included in this study. The 23 patients categorized as study group (S group) will use topical sulfasalazine prepared by dissolving one tablet of commercially available (COLOSALAZINE - EC 500 MG 20 TAB, manufactured by: Alexandria Company for Pharmaceuticals & Chemical Industries, Alexandria) in 100 ml of distilled water 4 times per day as a mouth wash combined with topical corticosteroids 4 times per day as a topical gel in an alternate sequence. There are no expected side effects of this treatment due to its topical application however, the patient will be instructed to stop the treatment if any adverse reactions occur such as allergy and coming to the clinic next day. - The 23 patients categorized as control group (C group) will receive topical corticosteroids gel only 4 times per day. The treatment regimen will be continued for 4 weeks with follow up visits one per week. - Medical history will be taken, thorough oral examination will be done, and a full questionnaire will be filled for each patient. - All participants in the study groups will undergo adequate oral hygiene performance measures with complete removal of plaque and calculus as they implement intraoral inflammation and intensify both extension and symptoms of OLP lesions. Patients will be advised to evade accidental trauma on soft tissues using soft bristles toothbrush. Acidic, spicy, hard, hot food and beverages will be avoided.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 46
Est. completion date November 20, 2023
Est. primary completion date November 1, 2023
Accepts healthy volunteers No
Gender All
Age group 30 Years to 65 Years
Eligibility Inclusion Criteria: - - Patients with 30-65 years old - Patents with atrophic OLP Exclusion Criteria: - - Smokers - pregnant or lactating ladies and - Patients under topical or systemic steroids during the last two months - Patients using lichenoid reaction-inducing drugs, - Patients with positive hepatitis C virus (HCV) antibodies, diabetes and hypertension - Patients having amalgam filling adjacent lesions will not also be included

Study Design


Intervention

Drug:
sulfasalazine 500 MG
The patients will use topical corticosteroids in addition to topical sulfasalazine 4 times per day.
corticosteroids
The patients will use topical corticosteroids 4 times per day.

Locations

Country Name City State
Egypt Faculty of Dentistry, Cairo University Cairo

Sponsors (1)

Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary NAS Scale for pain assessment Every week for 4 weeks period
Primary sign scoring scale of Thongprasom Score for severity Every week for 4 weeks period
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