Oral Lichen Planus Clinical Trial
Official title:
Adjunctive Effect of Topical Sulfasalazine for Oral Lichen Planus Management: A Randomized Clinical Trial
Verified date | September 2023 |
Source | Cairo University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucosal membrane. T-cell mediated damage against the mucosal epithelial cells is implicated in the pathogenesis of OLP, although the exact mechanism is unknown. Sulfasalazine is extensively used in inflammatory bowel disease and is effective on immune-related inflammatory disease such as Crohn's disease, rheumatoid arthritis, and Behcet's disease. In spite of its effectiveness, the anti-inflammatory mechanism is not clearly understood.
Status | Active, not recruiting |
Enrollment | 46 |
Est. completion date | November 20, 2023 |
Est. primary completion date | November 1, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 30 Years to 65 Years |
Eligibility | Inclusion Criteria: - - Patients with 30-65 years old - Patents with atrophic OLP Exclusion Criteria: - - Smokers - pregnant or lactating ladies and - Patients under topical or systemic steroids during the last two months - Patients using lichenoid reaction-inducing drugs, - Patients with positive hepatitis C virus (HCV) antibodies, diabetes and hypertension - Patients having amalgam filling adjacent lesions will not also be included |
Country | Name | City | State |
---|---|---|---|
Egypt | Faculty of Dentistry, Cairo University | Cairo |
Lead Sponsor | Collaborator |
---|---|
Cairo University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | NAS | Scale for pain assessment | Every week for 4 weeks period | |
Primary | sign scoring scale of Thongprasom | Score for severity | Every week for 4 weeks period |
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