Oral Lichen Planus Treatment

Status Completed

Clinical Trial Summary

Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease affecting the oral mucosa. OLP presents with asymptomatic, lacelike white stripes and/or symptomatic red, ulcerated mucous membranes. Eating, drinking and oral hygiene procedures may be painful resulting in reduced quality of life (QOL). Photodynamic therapy (PDT) is a new suggestion for OLP treatment PDT is a successful treatment mo- dality for premalignant and malignant diseases of head and neck,gastrointestinal tract, lung, and skin In this study, the effect of photodynamic therapy with topical corticosteroid in oral lichen planus patients was compared

Clinical Trial Description

In this study, the efficacy of toluidine blue-mediated photodynamic therapy and topical triamcinolone acetonide 0.2% on decreasing pain and size of OLP lesions was compared. This randomized, clinical trial compared the therapeutic effect of photodynamic therapy on symptomatic OLP (atrophic/ erosive/ulcerative forms) with triamcinolone acetonide 0.2%. The protocol of the clinical trial, which was conducted according to the ethical principles of Helsinki Group I toluidine blue-mediated photodynamic therapy Group II photodynamic therapy GroupIII laser sham + triamcinolone acetonide 0.2% ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05127083
Study type	Interventional
Source	Universidad de Murcia
Contact
Status	Completed
Phase	N/A
Start date	June 4, 2018
Completion date	October 18, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05997173` - The Regulatory Role of Immune Response in Oral Lichen Planus
Completed	`NCT02443311` - Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus	Phase 4
Completed	`NCT00484250` - Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other	Phase 2
Completed	`NCT03682562` - Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
Not yet recruiting	`NCT06428630` - Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus	Early Phase 1
Completed	`NCT04193748` - Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial)	Phase 4
Completed	`NCT04153266` - Oral Epithelial Dysplasia Informational Needs Questionnaire
Recruiting	`NCT06135805` - Impact of Fluocinonide 0,05% in Oral Lichen Planus	N/A
Completed	`NCT04289233` - Molecular & Cellular Characterisation of Oral Lichen Planus
Completed	`NCT04293718` - Acquired Chronic Erosive Gingivitis: Clinical Relevance of Papillary Gingival Biopsy
Completed	`NCT00525421` - A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus	Phase 2
Not yet recruiting	`NCT04091698` - Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial	Phase 1
Completed	`NCT03386643` - Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus	Phase 2
Withdrawn	`NCT03836885` - Apremilast - Oral Lichen Planus Trial	Phase 2
Completed	`NCT05730855` - Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
Completed	`NCT03257228` - The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2)	N/A
Recruiting	`NCT03026478` - Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus	Phase 2
Completed	`NCT02858297` - Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus	Phase 4
Completed	`NCT02834520` - Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus	N/A
Completed	`NCT02106468` - The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus	Phase 2