Oral Lichen Planus Clinical Trial
— (MDA)Official title:
The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker, Malondialdehyde [MDA] : Randomized Clinical Trial (RCT)
use seseme oil and corticosteroid topically for two groups
Status | Not yet recruiting |
Enrollment | 40 |
Est. completion date | December 30, 2020 |
Est. primary completion date | November 16, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patients who will be clinically diagnosed as having atrophic &/or erosive oral lichen planus. - Patients with no history of taking topical corticosteroids for the last 2 months and systemic corticosteroid for the last 6 months - Patients who agree to take medication and follow up . Exclusion Criteria: - Pregnant and lactating ladies. - Patients with history of topical steroids during last 2 months & systemic steroids during last 6 months. - Patients with recent dental filling associated with the lesion or associated with recent drug administration. - Patient with history of diabetes or hypertension or those with positive HCV ab or HBs Ag. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Mona Taha Mohammed MD |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | pain intensit measure | measured by visual analogue scale where0 no pain and 10 sever pain | 4 weeks | |
Primary | reduction of clinical signs measure | Thongprasom Score 5 = white striae with erosive area = 1 cm2 Score 4 = white striae with erosive area < 1 cm2 Score 3 = white striae with erosive area > 1 cm2 Score 2 = white striae with atrophic area < 1 cm2 Score 1 = mild white striae only Score 0 = no lesion normal | 4 weeks | |
Secondary | Salivary level of oxidative stress biomarker (MDA) | measured by reaction with thiobarbituric acid (TBA) | 4 weeks |
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