Oral Lichen Planus Clinical Trial
Official title:
Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treatment Oral LichenPlanus
Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease characterized by
outbreaks or flares. It affects 0.2-1.9% of the population. Although the etiology is
unknown, the pathogenesis of OLP is known to involve an immune disorder, with epithelial
damage caused by cytotoxic CD8 + lymphocytes. Clinically, the disease is characterized by
different types of lesions - papular, reticular and in the form of plaques - that can
alternate with erosive and/or ulcerative areas. A variety of treatments have been proposed
for OLP: topical or systemic corticosteroids, cyclosporine, retinoids, azathioprine,
tacrolimus, pimecrolimus, photochemotherapy and surgery. Patients with symptomatic OLP often
require intensive therapy to reduce the signs and symptoms. The disease can produce
considerable morbidity and alter patient quality of life, particularly in the presence of
ulcerative lesions.
There is no fully resolutive and effective treatment - the management strategy focusing on
the use of drugs that counter tissue inflammation and the underlying immunological
mechanisms. The main inconvenience of these treatments is represented by the side effects
they usually produce.
The purpose of this study was to evaluate that if Chamaemelum Nobile a can be used in the treatment of oral lichen planus. This could be useful as Chamaemelum Nobile has no reported side effects and hence it can used in place of steroids which are commonly used for this condition and have many reported adverse effects. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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