Effect of Two Toothpastes on Bacteria in Saliva

Status Completed

Clinical Trial Summary

This study investigated the ability of two zinc-containing toothpaste formulations (Zinc A and Zinc B) to reduce the level of bacteria in saliva in the two-hour period after their use, compared to the effect of rinsing with water alone.

Clinical Trial Description

This was a single centre, three treatment, randomized, blinded, cross-over study which involved rinsing with slurries of two sodium fluoride-silica dentifrices containing zinc chloride and sodium citrate, and with water alone. The study consisted of four Visits: Visit 1 (Screening), Visit 2 (Treatment 1), Visit 3 (Treatment 2), Visit 4 (Treatment 3). There was a minimum two days wash out period before the first treatment visit and between treatment visits to avoid any treatment carry-over effect. During that time participants brushed as normal (twice-daily) at home with a washout toothpaste and a toothbrush which was provided at screening. Participants were required not to brush their teeth on the morning of the treatment visits and not to eat or drink for 2 hours prior to the treatment visits. ;

Study Design

Related Conditions & MeSH terms

Oral Health

Clinical Trial Details

NCT number	NCT03587428
Study type	Interventional
Source	GlaxoSmithKline
Contact
Status	Completed
Phase	N/A
Start date	November 4, 2014
Completion date	November 27, 2014

View Details

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