Neuromuscular Ultrasonography Assessment of Optic Nerve in Systemic Lupus Eryhematosus

Optic Neuropathy Clinical Trial

Official title:

Neuromuscular Ultrasonography Assessment of Optic Nerve in SLE

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05853003
• Other study ID #: bending
• Status: Completed
• Start date: January 1, 2022
• Est. completion date: April 30, 2023

Study information

• Verified date: July 2023
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

assessing the role of neuromuscular ultrasound in optic nerve involvement in systemic lupus patients.

Description:

Evaluating the role of neuromuscular ultrasound in optic nerve involvement in systemic lupus patients.by measuring the diameter of optic nerve at certain site and comparing it to healthy subjects measurements and to asses NMUS ability to detect optic neuropathy in lupus patients in comparison to conventional techniques including opthalmologist evaluation and visual evoked potential

Recruitment information / eligibility

• Status: Completed
• Enrollment: 140
• Est. completion date: April 30, 2023
• Est. primary completion date: December 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 17 Years and older

Eligibility

Inclusion Criteria:

• Adult

• group of SLE patients, who fulfilled Systemic Lupus International Collaborating Clinics classification criteria for SLE (SLICC) with or without symptoms of optic neuropathy

• another group of apparently healthy subjects with no. history of chronic conditions

Exclusion Criteria:

• Any patient with optic neuritis due to causes other than lupus was excluded from the study: ex.

• Post traumatic neuropathy

• Purely degenerative neuropathy

• Diabetic neuropathy

• Toxic neuropathy

• Neuropathies related to infections

• Drug induced neuropathy e.g: quinine and some antibiotics, ethambutol

• Infections e.g. measles, mumps, Lyme disease, etc.

• Other Autoimmune diseases like sarcoidosis, B.D

• Tumor causing Inc. intracranial tension.

Related Conditions & MeSH terms

• Optic Nerve Diseases
• Optic Neuropathy

Locations

Country	Name	City	State
Egypt	Assuit university hospital	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Amira M elSonbaty

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	comparing diameter (in mm2) of optic nerve in SLE patients and compare them to healthy subjects	comparing diameter (in mm2) of optic nerve in SLE patients and compare them to healthy subjects	over 1 year