Optic Neuritis Clinical Trial
Retrobulbar optic neuritis (NORB) is the damage to the optic nerve caused by inflammation. It
causes a rapidly progressive and painful visual loss, often among young subjects. Diagnosis
confirmation is important to start proper treatment, because a NORB is often the first
symptom of multiple sclerosis. This diagnosis, based on a set of arguments, is difficult to
define by a non-expert ophthalmologist.
The pupillary light reflex is a way to test the visual afferent pathways. If it is subject to
a large inter-individual variability, the dynamics of the pupillary light reflex and its
latency are more reproducible. An easy way to study the dynamics of the pupillary light
reflex is to study the pupillary cycle time (PCT). In the case of NORB, elongation of the
conduction in the visual afferent pathways related to demyelination plate increases the
latency of the pupillary light reflex and decreases the frequency of the PCT.
Our hypothesis is that PCT dynamics measures would be a reliable indicator and easy to
evaluate some pathologies affecting the integrity of the nerve. The validation of a decrease
in the frequency of the PCT in NORB, compared to the frequency observed in subjects
ophthalmological or neurological disease, could help developing methods to study the
conduction of the visual pathways with portable devices used during the standard
ophthalmologic consultation and quickly orientate patients to specialized centers.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Unknown status |
NCT00261326 -
Simvastatin Treatment of Patients With Acute Optic Neuritis
|
Phase 3 | |
| Active, not recruiting |
NCT03963310 -
Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis
|
||
| Recruiting |
NCT03586557 -
Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis
|
N/A | |
| Recruiting |
NCT05487989 -
VIsual Pathways Model in Neuro-inflammatory Disorders
|
||
| Terminated |
NCT04131764 -
Diagnosis of ON With or Without MS or NMOSD
|
||
| Not yet recruiting |
NCT06453694 -
Efgartigimod for the Treatment of Acute Optic Neuritis
|
Phase 2 | |
| Completed |
NCT01962571 -
Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial
|
Phase 3 | |
| Recruiting |
NCT03302585 -
High-Dose Vitamin D Induction in Optic Neuritis
|
Phase 2 | |
| Recruiting |
NCT02886377 -
The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset
|
N/A | |
| Completed |
NCT01987167 -
Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis
|
Early Phase 1 | |
| Completed |
NCT01451593 -
Neuroprotection With Phenytoin in Optic Neuritis
|
Phase 2 | |
| Completed |
NCT03630497 -
BN201 SAD MAD Study in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT01337986 -
Ampyra for Optic Neuritis in Multiple Sclerosis
|
Phase 2/Phase 3 | |
| Completed |
NCT01274702 -
Visual Reconstitution Therapy After Optic Neuritis
|
Phase 2 | |
| Active, not recruiting |
NCT00445367 -
Biobank For MS And Other Demyelinating Diseases
|
||
| Withdrawn |
NCT00037115 -
Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.
|
Phase 4 | |
| Not yet recruiting |
NCT06389968 -
Light Stimulation to Improve Visual Function After Optic Neuritis in Persons With Multiple Sclerosis
|
N/A | |
| Recruiting |
NCT04257734 -
Epidemiologic and Clinical Characteristics of Optic Neuritis in China
|
||
| Completed |
NCT03753893 -
Ocular Manifestations in Rheumatic Diseases
|
||
| Completed |
NCT02939937 -
Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis
|
Phase 2 |