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Clinical Trial Summary

Comparison of high-resolution optical coherence tomography (High-Res-OCT) to conventional imaging modalities for the diagnosis of eye diseases


Clinical Trial Description

The high resolution optical coherence tomography (High-Res-OCT) is an improvement of a non-invasive routinely used imaging technique, the optical coherence tomography (OCT), with a light-source capable of providing an increased axial resolution. The routinely used Spectral-Domain OCT has a center wavelength of 880 nm and a spectral bandwidth of 40 nm, resulting in an axial resolution of approximately 7 μm in the eye and is used routinely worldwide. The High-Res OCT works with a central wavelength of 840 nm and an increased bandwidth of 130 nm, making it possible to improve the optical axial resolution in tissue from 7 to 3 µm, without increasing the maximum laser exposure limit. The improved axial resolution of the High-Res OCT results in clearer and more detailed images. The technique is routinely used in clinical practice and the device used for High-Res-OCT (Heidelberg, SPECTRALIS® High-Res OCT- DMR001) has received CE mark (european conformity in the extended Single Market in the European Economic Area) approval in March 2021. We plan to compare High-Res-OCT as an imaging modality to conventional imaging modalities used in clinical routine, such as the Spectral-Domain-OCT (SD-OCT) ;


Study Design


Related Conditions & MeSH terms

  • Diabetic Macular Edema
  • Diabetic Retinopathy
  • Edema
  • Glaucoma
  • Hypertensive Retinopathy
  • Macular Degeneration
  • Macular Disease
  • Macular Edema
  • Neovascularization, Pathologic
  • Optic Nerve Diseases
  • Papilledema
  • Retinal Artery Occlusion
  • Retinal Detachment
  • Retinal Disease
  • Retinal Diseases
  • Retinal Dystrophies
  • Retinal Dystrophy
  • Retinal Edema
  • Retinal Neovascularization
  • Retinal Vein Occlusion
  • Uveitis

NCT number NCT05130385
Study type Observational
Source University Hospital Inselspital, Berne
Contact Martin S Zinkernagel, MD, PhD
Phone +41316329565
Email martin.zinkernagel@insel.ch
Status Recruiting
Phase
Start date November 30, 2021
Completion date November 30, 2023

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