Optic Disc Drusen Clinical Trial
Official title:
Spectral Domain Optic Cohaerence Tomography Imaging in Patients With Optic Nerve Head Drusen
Optic nerve head Drusen are a mostly bilateral change of the optic nerve, eventually causing
a slow, but progression loss of the visual fields. Characteristic are the crystalline
deposits at the entrance of the optic nerve, the so called optic disc. The material consists
of calcium, calcium phosphate, iron, but also amino acids and polysaccharides.
The diagnose is made or confirmed by different imaging modalities like ultrasound and
auto-fluorescence imaging. By using the high-resolution imaging with spectral-domain optical
coherence imaging (SD-OCT) the volume and deposits at the optic disc can be measured and
quantified.
The purpose of this study whether and how defects in the visual fields are related to the
deposits. Multimodal imaging of the optic nerve head is planned within the cross-sectional
study, at two different time intervals (2 years). Changes in retinal fibre layer (RNFL)
thickness and disc parameters are analyzed. Presence and extent of auto-fluorescent changes
are evaluated. The prospective trial wants to clarify whether certain parameters at baseline
indicate the further outcome and development.
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