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Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use Disorder

Opioid Use Disorder Clinical Trial

Official title:
Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use Disorder: A Randomized Controlled Trial

Clinical Trial Summary

The current first-line treatment for opioid use disorder (OUD) in Canada is buprenorphine/naloxone (bup/nx). The standard induction method of bup/nx requires patients to be abstinent from opioids and thereby experience withdrawal symptoms prior to induction, which can be a major barrier in starting treatment. Rapid micro-induction (also known as micro-dosing, low-dose induction) involves the administration of small, frequent does of bup/nx and removes the need for a period of withdrawal prior to the start of treatment. This study aims to compare the effectiveness and safety of rapid micro-induction versus standard induction of bup/nx in patients with OUD.

Clinical Trial Description

This is a randomized, controlled, open-label superiority trial involving 50 individuals with OUD. Participants will be randomized into two arms: rapid micro-induction and standard induction (based on the American Society of Addiction Medicine Practice Guidelines and product monograph) of bup/nx. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04234191
Study type Interventional
Source University of British Columbia
Contact Pouya Azar, MD, FRCPC, DABAM
Phone 604-875-4111
Email pouya.rezazadeh-azar@ubc.ca
Status Recruiting
Phase Phase 2
Start date August 18, 2021
Completion date January 2025
View Details
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