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SMART Trial for Buprenorphine-Naloxone Medication Assisted Treatment Adherence

Opioid-use Disorder Clinical Trial

Official title:
Testing the Effects of Contingency Management and Behavioral Economics on Buprenorphine-Naloxone Treatment Adherence Using a Sequential Multiple Assignment Randomized Trial (SMART) Design

Clinical Trial Summary

The purpose of this study is to compare the effectiveness of two different interventions for medication-assisted treatment (MAT) adherence: Contingency Management (CM) and Brief Motivational Interviewing + Substance Free Activities + Mindfulness (BSM).

Clinical Trial Description

The investigators seek to compare the effectiveness of these two different interventions for MAT adherence by first refining and piloting CM and BSM adherence approaches, then conducting a Sequential Multiple Assignment Randomized Trial (SMART) to assess sequential, individual, and combined effects across MAT initiation and maintenance. In order to tailor treatment to individual's needs, the study will follow a sequential multiple assignment randomized trial (SMART) design: In stage 1, participants are individually randomized (1:1) to BSM or CM. Adherent buprenorphine-naloxone participants complete treatment in the arm they were originally assigned to, but non-adherent participants are re-randomized (1:1) to either switch to the other intervention or add the other intervention in this part-factorial SMART. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04080180
Study type Interventional
Source University of Tennessee
Contact
Status Enrolling by invitation
Phase N/A
Start date February 1, 2022
Completion date September 15, 2025
View Details
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