Opioid-use Disorder Clinical Trial
Official title:
NIDA CTN-0079: Emergency Department Connection to Care With Buprenorphine for Opioid Use Disorder
The purpose of this study is to learn what resources are needed to improve outcomes for
patients with opioid use disorder. The study will look at how patients engage in treatment
and the decisions that patients and providers make regarding treatment, specifically
buprenorphine treatment, for opioid use disorder.
The aims of this study are:
1. To evaluate using mixed methods the feasibility and acceptability of OUD screening,
ED-initiated BUP, and referral.
2. Over the course of the study and as XR-BUP is added to hospital formularies, to estimate
the percentage and confidence intervals of patients assessed, treated, and engaged in
treatment at Day 30. This will be a three-site study employing a multi-faceted approach
to facilitate clinical protocol implementation and to assess feasibility, acceptability,
and impact. Investigators will develop, introduce and update site-specific ED clinical
protocols and implementation plans for OUD screening, ED-initiated BUP, and referral for
treatment. A participatory action research approach will be utilized along with mixed
methods incorporating data derived from:
- Medical record and administrative data abstraction,
- Research assessments involving patients who are eligible for and willing to receive
ED-initiated BUP (including both those who do, and do not, receive BUP); these
assessments will document the index ED visit and the 30th day after the index ED
visit,
- Qualitative interviews, focus groups, and quantitative assessments involving
providers and staff, patients, and other stakeholders.
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