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Opioid Toxicity clinical trials

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NCT ID: NCT05391555 Recruiting - Clinical trials for Respiratory Depression

Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age

Start date: October 1, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a sensitive, discriminative indicator of opioid toxicity and respiratory depression among subjects aged 20-40 years old. Population data indicate that pupil size and PUAL decline slightly with age. The investigators will explore whether PUAL proves to be a sensitive indicator of opioid exposure and respiratory depression in this older group.

NCT ID: NCT04047550 Completed - Clinical trials for Ventilatory Depression

Respiratory Control and Narcotic Effects

Start date: March 8, 2018
Phase:
Study type: Observational

The aim of this study is to provide data that will assess the role of ventilatory chemosensitivity (respiratory drive) in determining postoperative respiratory depression due to opioids. In a group of patients requiring surgery and admission to hospital, before surgery, ventilatory chemosensitivity will be assessed in the presence or absence of an infusion of remifentanil. Parameters will be correlated with ventilatory depression events after surgery. A secondary aim is to determine whether respiratory depression is more likely during specific phases of sleep.