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Clinical Trial Summary

Opioid-induced bowel dysfunction is a frequent condition during opioid therapy for chronic pain. Indeed, up to 90% of people on opioid treated patients experience constipation. Standard laxative treatment is often ineffective in opioid-induced constipation, but peripheral acting mu-receptor antagonists (PAMORAs) have the potential to block the effects of opioids in the gastrointestinal tract while preserving the central analgesic effect. In this study, we will investigated the effects of Naldemedine in preventing the development of opioid-induced bowel dysfunction and constipation during treatment with tramadol


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06334198
Study type Interventional
Source Aalborg University Hospital
Contact Asbjørn Mohr Drewes
Phone +45 97 66 35 62
Email amd@rn.dk
Status Recruiting
Phase Phase 2
Start date March 12, 2024
Completion date March 2025

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