Opioid-free Anesthesia in VATS Lung Resection

Opioid Free Anesthesia Clinical Trial

Official title: The Effect of Opioid-free Anesthesia on Postoperative Analgesia-related Adverse Reactions in Lung Resection With Video-assisted Thoracoscopic Access: a Randomized Double-blind Controlled Study

Status Not yet recruiting

Clinical Trial Summary

A comparison of incidences of postoperative opioid-related adverse effects and recovery parameters in patients undergoing video-assisted thoracoscopic surgery (VATS) lung resection receiving opioid or opioid-free general anesthesia (OFA).

Clinical Trial Description

Video-assisted thoracoscopic surgery (VATS) lung resection is traditionally performed under general anesthesia with opioid‑based analgesia. It is associated with higher incidences of respiratory depression, hypotension, postoperative nausea and vomiting (PONV), dizziness, constipation and urinary retention, and more severe acute postoperative pain.

The purpose of our study is to compare the opioid‑free general anesthesia with the opioid‑based general anesthesia with respect to the primary outcome measures of the total incidence of opioid-related adverse effects (including respiratory depression, hypotension, PONV and dizziness) and secondary outcome measures of incidence of intraoperative and postoperative cardiovascular complications, pain relief, analgesic requirement , and other postoperative recovery parameters [e.g. duration of tracheal extubation, departing from post-anaesthesia care unit (PACU), exhaust, defecation, and stay in hospital postoperatively]. ;

Related Conditions & MeSH terms

• Opioid Free Anesthesia

• NCT number: NCT04507165
• Study type: Interventional
• Source: Peking University People's Hospital
• Contact: Feng Yi, MD,PhD
• Phone: 86-010-88325581
• Email: yifeng65@sina.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: August 2020
• Completion date: July 2022