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Clinical Trial Summary

The present study aims to assess the difference in postoperative opioid consumption between patients who intraoperatively receive a pecto-intercostal facial block combined with opioid-free anesthesia versus a traditional opioid-based regimen for cardiac surgery. The literature on opioid-free anesthesia for cardiac surgery is minimal and solely consists of case reports and retrospective studies. Nevertheless, these reports show the feasibility of opioid-free anesthesia. The purpose of this study is to assess the opioid-sparing effect and efficacy of combining an opioid-free anesthetic regimen with a pecto-intercostal fascial plane block (PIFB) in patients undergoing cardiac surgery. We hypothesize that opioid-free cardiac anesthesia with an intraoperative PIFB significantly reduces postoperative opioid consumption in comparison to a high-dose opioid intraoperative regimen.

Clinical Trial Description

Patients, aged 18 years or older, scheduled for coronary artery bypass graft surgery (CABG) with a complete midline sternotomy as surgical approach will be recruited for this study. Patients planned for this particular surgical procedure will be recruited and allocated to one of 2 groups: 1. "Intervention" group: Opioid-free anesthetic regimen with a pre-incisional pecto-intercostal fascial plane block (PIFB); 2. "Control" group: traditional opiate-based anesthetic regimen in which the dosage of the opioids is at the discretion of the attending anesthesiologist. Based on our power analysis, each group will consist of 64 patients. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04854577
Study type Interventional
Source Algemeen Stedelijk Ziekenhuis
Contact Koen Lapage, M.D.
Phone +32 53 764180
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date May 2021
Completion date September 2022

See also
  Status Clinical Trial Phase
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Completed NCT03120234 - Comparison of Opioid Based and Opioid Free Anaesthesia in Transsphenoidal Surgery N/A
Completed NCT03816592 - Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass