Clinical Trials Logo

Clinical Trial Summary

This study proposes to use functional magnetic resonance imaging (FMRI) to observe brain activity and behavior associated with decision-making about rewards (DD task), working memory and working memory cognitive persistence (WM task), and craving (CR task) in 72 opiate dependent participants initiating buprenorphine. While stably using opiates (initial study appointment) and again during withdrawal (approximately 3 days later), participants will receive an FMRI scan with behavioral challenges; immediately after the second FMRI, they will receive their first dose of buprenorphine. Buprenorphine treatment will continue for twelve weeks, followed by a four week taper. Urine toxicological analysis will be performed prior to the first scanning session, weekly for two weeks and biweekly thereafter. Participation for all individuals will last 4 months. Assessments will occur at baseline, and weeks 1, 2, 4, 8, and 12. Buprenorphine induction will begin at the completion of the second scan; follow-up medical visits will align with study assessments on weeks 1, 2, 4, 8 and 12. All participants will receive 16 weeks of buprenorphine (the final 4 of these 16 weeks will include a taper).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02696096
Study type Interventional
Source Butler Hospital
Contact
Status Completed
Phase Phase 3
Start date August 2016
Completion date February 2020

See also
  Status Clinical Trial Phase
Completed NCT04336293 - sTMS for Substance Use-disordered Veterans N/A
Completed NCT01188421 - Medications Development for Drug Abuse Disorders Phase 1/Phase 2
Completed NCT00499746 - The Discriminative Effects of Tramadol in Humans Phase 1/Phase 2
Not yet recruiting NCT05611749 - Duloxetine Impact on Postoperative Pain Control and Outcomes Phase 2
Recruiting NCT04325659 - An Innovative Intervention for OUD Treatment Phase 2/Phase 3
Completed NCT03685162 - Observational Study to Evaluate Levomethadone Safety and Effectiveness in Subjects Under Opioid Maintenance Treatment
Recruiting NCT04239235 - Integrating Support Persons Into Recovery N/A
Not yet recruiting NCT03394911 - Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addiction Phase 3
Not yet recruiting NCT02282072 - PINS Stimulator System for Deep Brain Stimulation of the Nucleus Accumbens to Treat Severe Opioid Addiction Phase 0
Not yet recruiting NCT01008072 - Ultra-rapid Opiate Detoxification Using Deep Sedation and Prior Oral Buprenorphine Preparation. N/A
Recruiting NCT05299515 - Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence N/A
Recruiting NCT04309565 - Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support N/A
Completed NCT01873989 - Testosterone Replacement for Male Opioid Agonist Maintained Patients Phase 1/Phase 2
Completed NCT01590251 - Yoga for Pain and Opioid Dependence Phase 1/Phase 2
Active, not recruiting NCT02866266 - ER/LA Opioid Surveillance for Emergency Department Visits and Hospitalizations for Overdose and Poisoning N/A
Enrolling by invitation NCT02871232 - Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers N/A