Employment-Based Depot Naltrexone Clinical Trial

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.

Clinical Trial Description

A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone adherence in opiate-dependent adults. An extended-release depot formulation of naltrexone will be used. Participants will be offered an inpatient opioid detoxification and naltrexone induction. Participants who complete the oral naltrexone induction will be randomly assigned to one of two groups. Both groups will be invited to work in the Therapeutic Workplace and will be prescribed depot naltrexone for 6 months. Patients in the "Work Plus Naltrexone Contingency" condition will earn access to working and earning salary by taking depot naltrexone once per month. "Work Plus Naltrexone Prescription" participants will be encouraged to take depot naltrexone monthly, but access to working and earning salary will not be contingent on doing so. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00684788
Study type	Interventional
Source	Johns Hopkins University
Contact
Status	Completed
Phase	Phase 2
Start date	May 2006
Completion date	May 3, 2009

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT03538444` - Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder	N/A
Completed	`NCT01690546` - Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence	Phase 2
Completed	`NCT01389167` - Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in Russia	Phase 3
Completed	`NCT01442493` - Reengineering Methadone Treatment Study of Patient-centered Methadone Treatment	N/A
Completed	`NCT01182402` - Electronic Compliance Monitoring in Opioid Substitution Treatment	N/A
Completed	`NCT00987961` - Linking Hospitalized Injection Drug Users to Buprenorphine	Phase 3
Completed	`NCT00634803` - Clinical Trial of Integrated Treatment for Pain and Opioid Dependence	Phase 1/Phase 2
Completed	`NCT00577408` - Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot Naltrexone	Phase 3
Completed	`NCT00539123` - Drug Counseling and Abstinent-Contingent Take-Home Buprenorphine in Malaysia	N/A
Completed	`NCT00566969` - Cocaine Withdrawal and Pharmacotherapy Response	N/A
Completed	`NCT00757744` - Behavioral Drug and HIV Risk Reduction Counseling in Methadone Patients in China	Phase 3
Recruiting	`NCT00241930` - Integrating Buprenorphine Into HIV Treatment	Phase 4
Completed	`NCT00218621` - The Effects of Methadone and Buprenorphine on Fetal Neurobehavior and Infant Neonatal Abstinence Syndrome - 1	Phase 2
Completed	`NCT00406484` - Brief Introductory Therapy for Opioid Dependence	Phase 2
Completed	`NCT00580827` - Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers	N/A
Completed	`NCT03015597` - Pilot Study of Contingency Management for Smoking Cessation	N/A
Completed	`NCT01393392` - Developing a Smoking Cessation Intervention for Methadone Maintained Smokers	Phase 1
Completed	`NCT01416584` - A Bridge to Treatment: The Therapeutic Workplace and Methadone Treatment	N/A
Recruiting	`NCT00439049` - Substance Abuse Pre-Treatment Screening Study
Withdrawn	`NCT00398008` - HIV Risk Reduction and Drug Abuse Treatment in Iran	Phase 2