Treatment of Polydrug-Using Opiate Dependents During Withdrawal

Status Completed

Clinical Trial Summary

Managed detoxification is a first and necessary step prior to treatment and rehabilitation. Detoxification can be a major obstacle for some patients, and the availability of managed and safe withdrawal is a prerequisite for long-term treatment.

In our clinical practice we have felt the need for a standardised and safe detoxification treatment regimen for our opioid addicts, as dependence on multiple drugs is so common.

Objectives

1. To assess whether a novel standardised treatment regimen - Buprenorphine (BPN) combined with Valproate (VPA) - will result in fewer withdrawal symptoms during detoxification of opiate–polydrug users than the existing treatment regimen, i.e. Clonidine (CLN) combined with Carbamazepine (CBZ).

2. To determine whether there are differences in treatment retention between the BPN/VPA and the CLN/CBZ groups.

3. To assess differences in clinical side-effects and biochemical interactions between the two treatment regimens.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00367874
Study type	Interventional
Source	Sorlandet Hospital HF
Contact
Status	Completed
Phase	Phase 4
Start date	February 2003
Completion date	November 2003

View Details

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