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Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8

Opiate Dependence Clinical Trial

Official title:
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals

Clinical Trial Summary

The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.

Clinical Trial Description

This is a 24-week, randomized, double-blind, placebo-controlled study examining two doses of modafinil (200 and 400 mg) and citalopram (20 and 40 mg) in the treatment of methadone maintained cocaine dependent individuals.

Participants will first be given methadone to determine its tolerated and effective doses. Most participants will be able to reach a stable dose of methadone within 7 to 10 days of methadone initiation. When 80% of the projected dose of methadone has been achieved, participants will begin the medication regimen of modafinil or citalopram. Modafinil will be given over a 7-day period. Dosing of modafinil will begin at 200 mg and, depending on the individual, may increase to 400 mg. Citalopram will be given in increasing doses, starting at 20 mg and increasing to 40mg. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00218036
Study type Interventional
Source The University of Texas Health Science Center, Houston
Contact
Status Terminated
Phase Phase 2
Start date July 2006
Completion date February 2010
View Details
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