Opiate Addiction Clinical Trial
Official title:
Advances in Opiate Detoxification Using the Combined Hemoperfusion-hemodialysis: A Comparison Study With Conventional Methadone Treatment (HPDMT)
The purpose of this study is to determine whether combined hemoperfusion-hemodialysis treatment is an alternative drug-free, effective, and safe treatment for opiate detoxification.
Drug abuse remains a major society problem in our community and is also a major health
problem in our modern society. Thus, education to prevent the young generation to avoid drug
abuse and detoxification to help those to quite from the drug abuse are two major key steps
in the controlling drug abuse program.
Currently, medications for opiate detoxification, such as methadone, are commonly used
worldwide. However, methadone is also an addictive medication. When it is stopped suddenly,
patients usually produce unpleasant withdrawal symptoms. Meanwhile, methadone is also
potentially to be abused too. Thus, it is urgently needed to seek an alternative safer,
effective, drug-free method for opiate detoxification. Based on our clinical observation,
the timely clearance of toxicities from the body or blood is a safe and effective
detoxification method. Thus, we hypothesized that the use of combined
hemoperfusion-hemodialysis may be an alternative drug-free, effective, and safe treatment
for opiate detoxification. This will be tested in patients who have severe drug abuse and
are under custodial conditions by a daily combined hemoperfusion-hemodialysis for 3 days.
The efficacy and safety of the hemoperfusion-hemodialysis will be compared to a 10 day
standard methadone detoxification treatment.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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