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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03105089
Other study ID # IRB00009910
Secondary ID
Status Completed
Phase N/A
First received April 2, 2017
Last updated October 27, 2017
Start date March 2016
Est. completion date May 2017

Study information

Verified date October 2017
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support


Description:

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ;pharmacologic or Physical) Pharmacological pc may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc ) Ischemic pc includes local ;remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs The liberated mediators have favorable effects not only upon the myocardium But ;it extend to protect other organs against inflammatory activation ;ischemia reperfusion injury Inotropic score IS is already an evident predictor of postoperative cardiac mobidity and mortality


Recruitment information / eligibility

Status Completed
Enrollment 60
Est. completion date May 2017
Est. primary completion date February 2017
Accepts healthy volunteers No
Gender All
Age group 16 Years to 60 Years
Eligibility Inclusion Criteria:

- adult patient

- valve replacement surgery

- ASA grade 2 or 3

Exclusion Criteria:

- emergency surgery

- - poor general conditions

- impaired hepatic or renal function

- peripheral vascular disease

- patient refusal

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
ischemic preconditioning
) ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Locations

Country Name City State
Egypt Emad Zarief Kamel Said Assiut

Sponsors (1)

Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary inotropic score 48 hours
Secondary renal function serum creatinine 2 dyas
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