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NCT02638181 Clinical Trial

The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork

Open-angle Glaucoma Clinical Trial

Official title:
The Expression of Matrix Metalloproteinase 13（MMP13）, Tissue Inhibitor of Metalloproteinases 3（TIMP13）, and Calcium-sensing Receptor（CaSR） in Human Trabecular Meshwork

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02638181
Other study ID # tjykdxykyy3
Secondary ID
Status Completed
Phase N/A
First received December 14, 2015
Last updated January 8, 2017
Start date July 2013
Est. completion date December 2015

Study information
Verified date January 2017
Source Tianjin Medical University Eye Hospital
Contact n/a
Is FDA regulated No
Health authority China: Tianjin Municipal Health Bureau
Study type Interventional

Clinical Trial Summary

This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date December 2015
Est. primary completion date December 2015
Accepts healthy volunteers No
Gender All
Age group 50 Years to 75 Years
Eligibility Inclusion Criteria:

- intraocular pressure greater than 22 mmHg with two or more medications

- wide anterior chamber angle

- glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect

- visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion Criteria:

- the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Procedure:
• trabeculectomy

Locations
Country Name City State
China Tianjin Medical University Eye Hospital Tianjin Tianjin

Sponsors (1)
Lead Sponsor Collaborator
Lv Yingjuan

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary the expressions of matrix metalloproteinase 13 and calcium-sensing receptor one hour after operation No
Secondary histological changes of trabecular meshwork one hour after operation No
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