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NCT00803803 Clinical Trial

Dose, Effects and Characteristics of Pilocarpine

Open-angle Glaucoma Clinical Trial

Official title:
Dose, Effects and Characteristics of Pilocarpine

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00803803
Other study ID # 08-914E
Secondary ID
Status Completed
Phase Phase 4
First received December 5, 2008
Last updated November 20, 2016
Start date August 1978
Est. completion date December 1979

Study information
Verified date November 2016
Source Wills Eye
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The purpose of this investigation, in which pilocarpine was given in repeated doses, was to evaluate: Part I - the effects of different concentrations of pilocarpine hydrochloride on intraocular pressure. Part II -the effects on intraocular pressure of glaucomatous patients to pilocarpine 2% when given once, twice and four daily. In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.

Description:

In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.

Recruitment information / eligibility
Status Completed
Enrollment 37
Est. completion date December 1979
Est. primary completion date August 1979
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 90 Years
Eligibility Inclusion Criteria:

- Primary open-angle glaucoma

- Primary open-angle glaucoma suspect

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• Pilocarpine Concentration
Varying concentration 0.5 to 8%
• Pilocarpine Frequency
1 to 4 times daily

Locations
Country Name City State
United States Wills Eye Glaucoma Service Philadelphia Pennsylvania

Sponsors (1)
Lead Sponsor Collaborator
Wills Eye

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Intraocular Pressure 25 days Yes
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