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NCT00481208 Clinical Trial

Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma

Open-Angle Glaucoma Clinical Trial

— IOPMG  

Official title:
Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00481208
Other study ID # 4-2006-0146
Secondary ID
Status Completed
Phase N/A
First received May 31, 2007
Last updated May 31, 2007
Start date March 2006
Est. completion date November 2006

Study information
Verified date May 2007
Source Yonsei University
Contact n/a
Is FDA regulated No
Health authority Republic of Korea: Institutional Review Board
Study type Observational

Clinical Trial Summary

Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients. In the results, we found a unique pattern, 'Latent asymmetric IOP', defined as the IOP which differs between the eyes only when placed in the supine position. Unique effects of this latent asymmetric IOP on Visual field and diurnal IOP fluctuations were studied.

Description:

Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow have been implicated to be one of the important factors to affect visual field progression. However, there was no study to investigate them in medically well-controlled open-angle glaucoma patients. So we want to find the unique patterns.

Study 1. Subjects : Patients with medically well controlled open angle glaucoma Method : IOP and peripapillary retinal blood flow were measured for 24 hours. The relationship between the two were studied.

Study 2. Of the patients enrolled in study 1 , those on the same medical regimen for both eyes were analyzed for the presence of a latent asymmetric IOP and it's influence and association with visual field and diurnal IOP fluctuation.

Recruitment information / eligibility
Status Completed
Enrollment 70
Est. completion date November 2006
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 20 Years to 70 Years
Eligibility Inclusion Criteria:

- Open-angle glaucoma

- Topical anti-glaucoma medications

Exclusion Criteria:

- Ocular surgery history

- Other ocular disease history

- Oral glaucoma medications

Study Design

Observational Model: Natural History, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Korea, Republic of Severance Hospital, Yonsei University College of Medicine Seoul

Sponsors (1)
Lead Sponsor Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

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