Ongoing Pregnancy Rate Clinical Trial
Official title:
High Versus Free Humidity Incubators; A Randomized Clinical Trial
To compare Top quality embryos either day3 or day 5, Pregnancy rate and most importantly ongoing pregnancy rate between high humidity incubators and humidity free incubators
When the IVF started the majority of incubators designed to support high humidity because
the designers and IVF specialists believed that the humidity will maintain stable ph and
Temp.
Recent reports suggest that humidity is recommended and the others suggest no difference So
we decide to go for this RCT. Nevertheless; high humidity is maintained in vivo (uterus and
fallopian tubes) due to the fluid content and stable body temperatures at 37°C. David
McCulloch reported 15% reduction of the miscarriage rate after changing the humidity from
76% to 100% (Textbook of Assisted Reproductive Techniques: Laboratory Perspectives, Fourth
Edition). Some embryologists claim that the humidity free incubators may increase the chance
of chemical pregnancy and early fetal loss (Private center IbnSina IVF, Sohag, Egypt.
unpublished data). This observations are never tested in a well designed randomized clinical
trial (RCT) to eliminate the probability of chance and to reach a solid evidence.
The question that should be asked : is high humidity culture should be applied or there is
no difference between dry and high humidity culture conditions?
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Health Services Research
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