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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05907525
Other study ID # 05-2023-133
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date June 29, 2023
Est. completion date June 30, 2024

Study information

Verified date September 2023
Source Pusan National University Yangsan Hospital
Contact Jung-Pil Yoon, MD
Phone 820553602129
Email wizdumb@naver.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The goal of this clinical trial is to compare the effect of sevoflurane and remimazolam on arterial oxygenation during one lung ventilation in patients undergoing video-assisted thoracoscopic surgery.


Description:

One lung ventilation (OLV) is a mechanical ventilation method used during thoracic surgery to collapse the non-ventilated lung and secure the surgical field. During one lung ventilation, the pulmonary artery of the collapsed lung undergoes vasoconstriction in response to hypoxia, which increases the blood flow of the normally ventilated lung as a compensatory physiological response. This is known as hypoxic pulmonary vasoconstriction (HPV). Therefore, by using HPV, arterial blood oxygenation can be maintained and pulmonary shunting can be reduced, preventing hypoxemia during one lung ventilation. The two most commonly used anesthetics in thoracic surgery are sevoflurane, an inhaled anesthetic, and propofol, an intravenous anesthetic. Previous studies have shown that there were no significant differences between two anesthetics on arterial oxygenation during one lung ventilation because sevoflurane administered in clinical concentrations of 1 minimum alveolar concentration (MAC) resulted in similar changes in shunt fraction as did propofol. However, the effect of remimazolam on arterial blood oxygenation and intrapulmonary shunt during one lung ventilation has not been revealed. Therefore, this study is designed to compare the effect of remimazolam and sevoflurane anesthesia on arterial oxygenation during one lung ventilation in patients undergoing video-assisted thoracoscopic surgery.


Recruitment information / eligibility

Status Recruiting
Enrollment 58
Est. completion date June 30, 2024
Est. primary completion date June 30, 2024
Accepts healthy volunteers No
Gender All
Age group 19 Years to 79 Years
Eligibility Inclusion Criteria: - Patients undergoing video-assisted thoracoscopic surgery - 19 years of age or older, less than 80 years old - The American Society of Anesthesiologists (ASA) classification I-? physical status Exclusion Criteria: - Patients with known allergy to benzodiazepine, propofol - Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption - Patients with hypersensitivity to Dextran40 - Patients with end stage renal disease requiring hemodialysis - Patients with history of acute angle glaucoma - Emergency operation - Patients with unstable hemodynamics requiring inotropics - Patients with preoperative oxygen supplement - Preoperative forced expiratory volume (FEV1) less than 40% of predicted - Preoperative ejection fraction less than 50%

Study Design


Intervention

Drug:
Remimazolam
To induce anesthesia, remimazolam is continuously infused in a dose of 6mg/kg/hr with remifentanil (Ce of 1-4ng/ml) by target-controlled infusion (TCI). Maintenance dose of remimazolam is 1mg/kg/hr, up to 2mg/kg/hr, and remifentanil is titrated to maintain the bispectral index (BIS) between 40 and 60 to achieve appropriate anesthetic depth during general anesthesia. Inspired oxygen fraction (FiO2) 1.0 is used during mask ventilation and tracheal intubation. During two lung ventilation (TLV), tidal volumes (8mL/kg predicted body weight), positive end-expiratory pressure (PEEP) 5cmH2O with FiO2 0.3 is applied. At the start of one lung ventilation(OLV), tidal volumes (5mL/kg predicted body weight), PEEP 5cmH2O with FiO2 0.8 is applied. Intraoperative ventilatory frequency is 12 breaths/min, subsequently adjusted to maintain end tidal CO2(ETCO2) ranged between 35-40mmHg.
1% propofol
To induce anesthesia, 1% propofol 1.5-2.5mg/kg is used with remifentanil (Ce of 1-4ng/ml) by target-controlled infusion (TCI). After patient loses consciousness, anesthesia is maintained through the inhalation of sevoflurane between 1-2 minimum alveolar concentrations (MAC), and remifentanil is titrated to maintain the bispectral index (BIS) between 40 and 60 to achieve appropriate anesthetic depth during general anesthesia. Inspired oxygen fraction (FiO2) 1.0 is used during mask ventilation and tracheal intubation. During two lung ventilation (TLV), tidal volumes (8mL/kg predicted body weight), positive end-expiratory pressure (PEEP) 5cmH2O with FiO2 0.3 is applied. At the start of one lung ventilation(OLV), tidal volumes (5mL/kg predicted body weight), PEEP 5cmH2O with FiO2 0.8 is applied. Intraoperative ventilatory frequency is 12 breaths/min, subsequently adjusted to maintain end tidal CO2(ETCO2) ranged between 35-40mmHg.

Locations

Country Name City State
Korea, Republic of Pusan National University Yangsan Hospital Yangsan Please Select

Sponsors (1)

Lead Sponsor Collaborator
Pusan National University Yangsan Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type Measure Description Time frame Safety issue
Other cardiac output Compare the cardiac output using Masimo LiDCO™ hemodynamic monitoring system During 60 minutes of OLV
Other airway pressure Compare the peak airway pressure between two groups During 60 minutes of OLV
Primary PaO2 after 30 minutes of OLV (T2) compare the arterial oxygenation after 30 minutes of one lung ventilation between two groups arterial blood sampling will be taken over four times: T0 (after 10 minute of TLV in lateral decubitus position), T1 (after 15 minutes of OLV), T2 (after 30 minutes of OLV), T3 (after 60 minutes of OLV)
Secondary Changes of PaO2 Compare the changes of PaO2 between two groups. During 60 minutes of OLV
Secondary Changes of PaCO2 Compare the changes of PaCO2 between two groups. During 60 minutes of OLV
Secondary Changes of P/F ratio Compare the changes of PaO2/FiO2 ratio between two groups. During 60 minutes of OLV
Secondary The lowest PaO2 Compare the lowest PaO2 between two groups. During 60 minutes of OLV
Secondary Changes of ORI Compare the changes of oxygen reserve index between two groups. During 60 minutes of OLV
Secondary Changes of MAP Compare the changes of mean arterial pressure between two groups. During 60 minutes of OLV
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