One-Lung Ventilation Clinical Trial
Official title:
Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation: a Prospective Randomized Controlled Study
The goal of this clinical trial is to compare the effect of sevoflurane and remimazolam on arterial oxygenation during one lung ventilation in patients undergoing video-assisted thoracoscopic surgery.
Status | Recruiting |
Enrollment | 58 |
Est. completion date | June 30, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 19 Years to 79 Years |
Eligibility | Inclusion Criteria: - Patients undergoing video-assisted thoracoscopic surgery - 19 years of age or older, less than 80 years old - The American Society of Anesthesiologists (ASA) classification I-? physical status Exclusion Criteria: - Patients with known allergy to benzodiazepine, propofol - Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption - Patients with hypersensitivity to Dextran40 - Patients with end stage renal disease requiring hemodialysis - Patients with history of acute angle glaucoma - Emergency operation - Patients with unstable hemodynamics requiring inotropics - Patients with preoperative oxygen supplement - Preoperative forced expiratory volume (FEV1) less than 40% of predicted - Preoperative ejection fraction less than 50% |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Pusan National University Yangsan Hospital | Yangsan | Please Select |
Lead Sponsor | Collaborator |
---|---|
Pusan National University Yangsan Hospital |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | cardiac output | Compare the cardiac output using Masimo LiDCO™ hemodynamic monitoring system | During 60 minutes of OLV | |
Other | airway pressure | Compare the peak airway pressure between two groups | During 60 minutes of OLV | |
Primary | PaO2 after 30 minutes of OLV (T2) | compare the arterial oxygenation after 30 minutes of one lung ventilation between two groups | arterial blood sampling will be taken over four times: T0 (after 10 minute of TLV in lateral decubitus position), T1 (after 15 minutes of OLV), T2 (after 30 minutes of OLV), T3 (after 60 minutes of OLV) | |
Secondary | Changes of PaO2 | Compare the changes of PaO2 between two groups. | During 60 minutes of OLV | |
Secondary | Changes of PaCO2 | Compare the changes of PaCO2 between two groups. | During 60 minutes of OLV | |
Secondary | Changes of P/F ratio | Compare the changes of PaO2/FiO2 ratio between two groups. | During 60 minutes of OLV | |
Secondary | The lowest PaO2 | Compare the lowest PaO2 between two groups. | During 60 minutes of OLV | |
Secondary | Changes of ORI | Compare the changes of oxygen reserve index between two groups. | During 60 minutes of OLV | |
Secondary | Changes of MAP | Compare the changes of mean arterial pressure between two groups. | During 60 minutes of OLV |
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