Heated Circuit for One-lung Ventilation

One-lung Ventilation Clinical Trial

Official title:

Effect of Heated-humidified Circuit on Arterial Oxygenation in Patients Undergoing One-lung Ventilation for Thoracoscopic Surgery

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03649386
• Other study ID #: HeatOLV
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 1, 2018
• Est. completion date: December 1, 2019

Study information

• Verified date: August 2018
• Source: Keimyung University Dongsan Medical Center
• Contact: Hyun-Chang Kim, MD Ph
• Phone: +821028862876
• Email: onidori1979[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 104
• Est. completion date: December 1, 2019
• Est. primary completion date: September 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 80 Years

Eligibility

Inclusion Criteria:

• American Society of Anesthesiologist class I-II

• Patients scheduled for one-lung ventilation for thoracoscopic surgery

Exclusion Criteria:

• Obesity

• Severe obstructive or restrictive lung disease

• Preoperative oxygen supply

• Preoperative intubated state or under mechanical ventilatory support

• Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg

• Symptomatic coronary or peripheral arterial disease

• Renal failure

• Preoperative continuous infusion of inotropes or vasopressor

• Pregnancy

Related Conditions & MeSH terms

• One-lung Ventilation
• Oxygenation
• Temperature

Intervention

Device:
• Heated and humidified breathing circuit on
Heated and humidified breathing circuit will be turned on.
• Heated and humidified breathing circuit off
Heated and humidified breathing circuit will be turned off.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Keimyung University Dongsan Medical Center

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Arterial oxygenation	Arterial oxygenation (mmHg) will be measured by arterial blood analysis.	At 30 minutes after one-lung ventilation
Secondary	Arterial oxygenation	Arterial oxygenation (mmHg) will be measured by arterial blood analysis.	At 0, 15, 45, and 60 minutes after one-lung ventilation
Secondary	Mean arterial pressure	Mean arterial pressure (mmHg) will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Heart rate	Heart rate (beats/min) will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Temperature	Body temperature (°C) will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Central venous pressure	Mean central venous pressure (mmHg) will be measured by a central venous catheter.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Cardiac index	Cardiac index (l/min/m^2) will be measured by pulse-contour analysis.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Pressure peak	Peak pressure of ventilation (cmH2O) will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Pressure plateau	Plateau pressure of ventilation (cmH2O) will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Arterial carbon dioxide	Arterial carbon dioxide will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Arterial blood acidosis	Arterial blood acidosis will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation
Secondary	Oxygen saturation of arterial blood	Oxygen saturation of arterial blood (%) will be measured.	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation