Preconditioning of One-lung Ventilation

One Lung Ventilation Clinical Trial

Official title:

Preconditioning of One-lung Ventilation for Lung Protection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03282032
• Other study ID #: JHSeo_preconditioning
• Status: Completed
• Phase: N/A
• Start date: November 22, 2017
• Est. completion date: October 13, 2018

Study information

• Verified date: August 2018
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.

Description:

For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia.

Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation.

Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery

Recruitment information / eligibility

• Status: Completed
• Enrollment: 136
• Est. completion date: October 13, 2018
• Est. primary completion date: October 9, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

• Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position

Exclusion Criteria:

• Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease

• Thoracic surgery for pneumonectomy

Related Conditions & MeSH terms

• One Lung Ventilation

Intervention

Other:
• One-lung ventilation
The patient undergoing thoracic surgery is intubated with double lumen tube after induction of general anesthesia with propofol and remifentanil. In the intervention group, 5 cycles of one-lung ventilation preconditioning (2-min of one-lung ventilation and 2-min of two-lung ventilation for 1 cycle) is performed before surgical incision. One-lung ventilation is done at dependent lung with FiO2 100% and tidal volume 6 ml kg-1. Two-lung ventilation is done with FiO2 50%, tidal volume 8 ml kg-1.

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (1)

Benumof JL. Intermittent hypoxia increases lobar hypoxic pulmonary vasoconstriction. Anesthesiology. 1983 May;58(5):399-404. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of hypoxemia	SpO2 < 95%	during one-lung ventilation, up to 5 hours
Primary	P/F ratio	PaO2/FIO2 ratio	30min after surgical incision
Secondary	Pulmonary complications	Acute lung injury, acute respiratory distress syndrome, atelectasis, pneumonia	6, 24, 48 hours after surgery, during hospital stay.