Clinical Trials Logo

Ondansetron clinical trials

View clinical trials related to Ondansetron.

Filter by:
  • Completed  
  • Page 1

NCT ID: NCT03833999 Completed - Ondansetron Clinical Trials

Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea

MOLID
Start date: October 16, 2018
Phase: Phase 4
Study type: Interventional

This is a double-blind, two period, two treatment crossover trial of ondansetron verses placebo studying the effects of ondansetron in the small and large bowel, specifically its effects on the amount of water in the gut, measured by MRI.

NCT ID: NCT03629522 Completed - Cesarean Section Clinical Trials

Effects of Ondansetron on Hemodynamics in Cesarean Section Under Spinal Anesthesia

EffOnd
Start date: August 1, 2017
Phase: Phase 4
Study type: Interventional

BACKGROUND: Spinal anesthesia (SA) induced maternal hypotension is the most frequent and troublesome complication in cesarean section (CS), compromising both maternal and neonatal well-being. Many strategies have been used to prevent its occurrence but no single technique has been confirmed to be completely effective. the investigators hypothesized that ondansetron, a serotonin-receptor-antagonist, could have beneficial effects on maternal hemodynamics during CS under SA. METHODS: In this prospective double-blind placebo-controlled study, one hundred healthy parturients were randomized to receive either 8 mg of intravenous ondansetron (group O) or the same volume of saline (group S), 5 minutes prior to the induction of SA. All women received a coloading volume of 500 ml of saline. Maternal hemodynamics: blood pressure, heart rate and cardiac output (CO) were measured with a non-invasive device based on pulse wave transit time: the esCCO device Nihon Kohden hemodynamic monitor. Ephedrine was administered to treat hypotension (systolic blood pressure less than 80% of baseline).

NCT ID: NCT01759420 Completed - Ondansetron Clinical Trials

Ondansetron and the QT Interval In Adult Emergency Department Patients

Start date: December 2012
Phase: N/A
Study type: Observational

The purpose of this study is to assess the use of the medication ondansetron (zofran) in the emergency department. There are studies of the ability of ondansetron to cause a prolongation in the QT interval (a certain measurement on an EKG) in anesthesia and cancer patients, but not on emergency department patients. This is an observational study where patients that are going to receive the anti-nausea medicine ondansetron in the emergency department will have an EKG performed every 2 minutes for 20 minutes to determine if the QT interval prolongs and returns to normal in that time period. Any serious outcomes will be reported. There is expected to be no adverse outcomes from this routinely used medication.