Oncology Clinical Trial
Official title:
Multiscale Modeling / Simulation of the Response to Pulmonary Stereotactic Hypofractionated Irradiation
Identify 18-Fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) parameters predictive of tumor response and local control
The identification of robust prognostic and predictive markers could allow the
individualization of pulmonary stereotactic radiotherapy treatments and the selection of
patients at high risk of relapse, who could then benefit from a dose escalation in order to
increase the chances of local control .
Beyond the pulmonary RTS (Radiotherapy in stereotactic condition), this study will aim to
generate one or more models of multi-scale response to hypofractionated irradiation from
biomarkers (biological or images) extracted from preclinical or clinical literature data and
to allow simulations of Various modified fractionation irradiation schemes, potentially
leading to new regimens that reduce side effects and increase therapeutic efficacy.
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