Is Pentoxifylline Able to Improve Olfactory Sensitivity?

Status Completed

Clinical Trial Summary

Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.

Clinical Trial Description

Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function. ;

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Olfaction Disorders

Clinical Trial Details

NCT number	NCT00660868
Study type	Observational
Source	Technische Universität Dresden
Contact
Status	Completed
Phase	N/A
Start date	November 2009
Completion date	January 2016

View Details

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